QuickView for il6 (gene)

Gene Symbol:

IL6 Homo sapiens

Full name:

interleukin 6

Synonyms:

BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6, interleukin-6, B-cell differentiation factor, B-cell stimulatory factor 2, CTL differentiation factor, hybridoma growth factor, interferon beta-2, interleukin BSF-2

Genomic Location:

Chr 7: 22733343-22738145

Description:

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the...

View Full Description

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  IRF1_01 ,  OCT1_05 ,  TGANTCA_AP1_C ,  TGGNNNNNNKCCAR_UNKNOWN ,  TGANNYRGCA_TCF11MAFG_01 ,  NFE2_01 ,  AP1_Q6_01 ,  GTGACGY_E4F1_Q6 ,  AP1_01 ,  AP1FJ_Q2 ,  NRF2_Q4 ,  AP1_Q4 ,  GATA1_05 ,  IK1_01 ,  AP1_Q2 ,  CCANNAGRKGGC_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  GCTNWTTGK_UNKNOWN ,  GGGNNTTTCC_NFKB_Q6_01 ,  GGGTGGRR_PAX4_03 ,  TCF11MAFG_01 ,  TGASTMAGC_NFE2_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-26

Cytogenetic Map:

7p15.3

search → result