Bookmark
Forward
QuickView for imipenem (compound)
PubChem
| Name: | Imipenem |
|---|---|
| PubChem Compound ID: | 104838 |
| Description: | Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor. |
| Molecular formula: | C12H17N3O4S |
| Molecular weight: | 299.347 g/mol |
| Synonyms: |
N-Formimidoylthienamycin; Imipenem anhydrous; Imipemide; AIDS-007648; 64221-86-9; IMP; Imipenem, N-Formimidoyl thienamycin; [5R-[5.alpha.,6.alpha.(R*)]]-6-(1-Hydroxyethyl)-3-[[2- [(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2- ene-2-carboxylic acid monohydrate; Prestwick1_000519; Prestwick0_000519.
show more » |
DrugBank
Identification
| Name: | Imipenem |
|---|---|
| Name (isomeric): | DB01598 |
| Drug Type: | small molecule |
| Description: | Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor. |
| Synonyms: |
Imipemide; N-formimidoylthienamycin; Imipenem, n-formimidoyl thienamycin; IMP
|
| Brand: | Tienamycin |
| Category: | Anti-Bacterial Agents |
| CAS number: | 74431-23-5 |
Pharmacology
| Indication: | For the treatment of bacterial infections caused by susceptible bacteria. |
|---|---|
| Pharmacology: |
Imipenem is a beta-lactam antibiotic belongings to the subgroup of carbapenems. Imipenem has a broad spectrum of activity against aerobic and anaerobic Gram positive as well as Gram negative bacteria. It is particularly important for its activity against Pseudomonas aeruginosa and the Enterococcus species. Imipenem is rapidly degraded...
show more » |
| Mechanism of Action: |
Imipenem acts as an antimicrobial through the inhibition of cell wall synthesis of various gram-positive and gram-negative bacteria. This inhibition of cell wall synthesis in gram-negative bateria is attained by binding to pencillin binding proteins (PBPs). In E. coli and selected strains of P. aeruginosa, imipenem has shown to have the highest aff...
show more » |
| Absorption: | Imipenem is not effectively absorbed from the gastrointestinal tract and therefore must be administered parenterally. |
| Protein binding: | 20% binds to plasma proteins |
| Biotransformation: | Renal. |
| Half Life: | 1 hour |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
| Drug interaction: |
|
|---|
Targets
