Name: | Indomethacin |
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PubChem Compound ID: | 3715 |
Description: | A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes. |
Molecular formula: | C19H16ClNO4 |
Molecular weight: | 357.787 g/mol |
Synonyms: |
Mezolin; Indometacina [INN-Spanish]; Idomethine; Indo-Phlogont; Indometacin; Artrivia; alpha-(1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl)acetic acid; Indometacine [INN-French]; Indacin; Indacin R potassium salt.
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Name: | Indomethacin |
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Name (isomeric): | DB00328 |
Drug Type: | small molecule |
Description: | A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes. |
Synonyms: |
Indomethancin; Indometicina; Indomethacinum; Indomethine; Indometacine; Indometacyna; Indomethacine; IMN; Indomethazine
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Brand: | Reumacide, Artrinovo, Dolcidium, Indocid Pda, Liometacen, Tannex, Arthrexin, Metartril, Sadoreum, Nu-Indo, Rhemacin La, Mikametan, Indomethegan, Indo-Rectolmin, Inflazon, Indomecol, Bonidon, Catlep, Indocin I.V., Indo-Phlogont, Bonidon Gel, Flexin Continus, Chrono-Indocid, Confortid, Indocid, Hicin, Miametan, Rheumacin La, Indo-Lemmon, Indocin I.V, Indocin, Indoptic, Indorektal, Indocin Sr, Artracin, Indocid Sr, Vonum, Mobilan, Bonidin, Indameth, Indaflex, Novo-Methacin, Durametacin, Dolovin, Artrivia, Chibro-Amuno, Indomo, Apo-Indomethacin, Indomed, Indomee, Methazine, Indolar Sr, Argun, Indoxen, Dolcidium Pl, Indmethacine, Metindol, Amuno, Novomethacin, Idomethine, Indo-Spray, Imbrilon, Indo-Tablinen, Elmetacin, Indomod, Inacid, Inteban Sp, Metacen, Indacin, Lausit, Infrocin, Chrono-Indicid, Indoptol |
Category: | Tocolytic Agents, Cyclooxygenase Inhibitors, Cardiovascular Agents, Gout Suppressants, Anti-inflammatory Agents, Nonsteroidal Anti-inflammatory Agents (NSAIAs) |
CAS number: | 53-86-1 |
Indication: | For moderate to severe rheumatoid arthritis including acute flares of chronic disease, ankylosing spondylitis, osteoarthritis, acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis. |
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Pharmacology: |
Indomethacin, a NSAIA, with analgesic and antipyretic properties exerts its pharmacological effects by inhibiting the synthesis of prostaglandins involved in pain, fever, and inflammation. Indomethacin inhibits the catalytic activity of the COX enzymes, the enzymes responsible for catalyzing the rate-limiting step in prostaglandin synthesis via the...
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Mechanism of Action: |
Indomethacin is a prostaglandin G/H synthase (also known as cyclooxygenase or COX) inhibitor that acts on both prostaglandin G/H synthase 1 and 2 (COX-1 and -2). Prostaglandin G/H synthase catalyzes the conversion of arachidonic acid to a number of prostaglandins involved in fever, pain, swelling, inflammation, and platelet aggregation. Indomethaci...
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Absorption: | Bioavailability is approximately 100% following oral administration and 80–90% following rectal administration. |
Protein binding: | 97% |
Biotransformation: | Hepatic. |
Route of elimination: | Indomethacin is eliminated via renal excretion, metabolism, and biliary excretion. |
Half Life: | 4.5 hours |
Toxicity: | The following symptoms may be observed following overdosage: nausea, vomiting, intense headache, dizziness, mental confusion, disorientation, or lethargy. There have been reports of paresthesias, numbness, and convulsions. The oral LD50 of indomethacin in mice and rats (based on 14 day mortality response) was 50 and 12 mg/kg, respectively. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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