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QuickView for inosine monophosphate (compound)

Summary
General Info

PubChem

PubChem Compound 10234953

Name:	Inosine Monophosphate
PubChem Compound ID:	10234953
Description:	Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
Molecular formula:	C₁₀H₁₃N₄O₈P
Molecular weight:	348.206 g/mol

DrugBank

Identification

Name:	Inosine Monophosphate
Name (isomeric):	DB04566
Drug Type:	small molecule
Description:	Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
CAS number:	131-99-7

Targets

Inosine-5'-monophosphate dehydrogenase

Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH

UniProt ID:

P0C0H6

Gene:

guaB

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Adenylosuccinate synthetase isozyme 1

Plays an important role in the de novo pathway of purine nucleotide biosynthesis

UniProt ID:

Q8N142

Gene:

ADSSL1

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
View Article

Hypoxanthine phosphoribosyltransferase

This enzyme acts exclusively on hypoxanthine; it does not act on guanine

UniProt ID:

P0A9M2

Gene:

hpt

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Adenylosuccinate synthetase

Plays an important role in the de novo pathway of purine nucleotide biosynthesis

UniProt ID:

Q83P33

Gene:

purA

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Hypoxanthine-guanine phosphoribosyltransferase, putative

GMP + diphosphate = guanine + 5-phospho-alpha- D-ribose 1-diphosphate

UniProt ID:	Q27796
Gene:	HGPRTase
Actions:	unknown

Glycogen phosphorylase, muscle form

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

UniProt ID:

P11217

Gene:

PYGM

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
View Article

Adenylosuccinate synthetase

Plays an important role in the de novo pathway of purine nucleotide biosynthesis

UniProt ID:

P0A7D4

Gene:

purA

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Inosine-5'-monophosphate dehydrogenase 2

Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors

UniProt ID:

P12268

Gene:

IMPDH2

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
View Article

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