QuickView for insulin-like growth factor-1 (gene)

Gene Symbol:

IGF1 Homo sapiens

Full name:

insulin like growth factor 1

Synonyms:

IGF-I, IGFI, MGF, insulin-like growth factor I, insulin-like growth factor 1 (somatomedin C), insulin-like growth factor IB, mechano growth factor, somatomedin-C

Genomic Location:

Chr 12: 101313806-101398454

Description:

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative...

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The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  TTTGCAC_MIR19A_MIR19B ,  SMTTTTGT_UNKNOWN ,  STAT4_01 ,  AGCYRWTTC_UNKNOWN ,  MYOD_01 ,  GCATTTG_MIR105 ,  TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  AREB6_02 ,  GATA3_01 ,  SRF_Q6 ,  CATTGTYY_SOX9_B1 ,  TTTGTAG_MIR520D ,  YATTNATC_UNKNOWN ,  HP1SITEFACTOR_Q6 ,  TACTTGA_MIR26A_MIR26B ,  ACTTTAT_MIR1425P ,  FAC1_01 ,  AGGAGTG_MIR483 ,  E2A_Q2 ,  CTAWWWATA_RSRFC4_Q2 ,  RFX1_01 ,  GATA1_04 ,  HEB_Q6 ,  COMP1_01 ,  WTGAAAT_UNKNOWN ,  TGAYRTCA_ATF3_Q6 ,  TATAAA_TATA_01 ,  ACATTCC_MIR1_MIR206 ,  TTGGGAG_MIR150 ,  GCACCTT_MIR18A_MIR18B ,  CAGGTA_AREB6_01 ,  RP58_01 ,  ETS2_B ,  AP4_01 ,  TGCGCANK_UNKNOWN ,  EVI1_05 ,  GTTTGTT_MIR495 ,  ATF3_Q6 ,  YKACATTT_UNKNOWN ,  GAANYNYGACNY_UNKNOWN ,  RAAGNYNNCTTY_UNKNOWN ,  OCT1_06 ,  FREAC2_01 ,  AACATTC_MIR4093P ,  TTGTTT_FOXO4_01 ,  AAAYRNCTG_UNKNOWN ,  STAT5A_04 ,  HEN1_02 ,  TEF_Q6 ,  GTGGGTGK_UNKNOWN ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CCCNNNNNNAAGWT_UNKNOWN ,  TCCATTKW_UNKNOWN ,  TBP_01 ,  CAGCTG_AP4_Q5 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  TGACATY_UNKNOWN ,  PAX2_02 ,  FREAC4_01 ,  GGGTGGRR_PAX4_03 ,  HOX13_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-486 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496

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Cytogenetic Map:

12q23.2

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