QuickView for interleukin 13 (gene)

Gene Symbol:

IL13 Homo sapiens

Full name:

interleukin 13

Synonyms:

IL-13, P600, interleukin-13

Genomic Location:

Chr 5: 132021764-132024700

Description:

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the produc...

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This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  ETS_Q4 ,  TTANTCA_UNKNOWN ,  GATA3_01 ,  AML_Q6 ,  NFKAPPAB_01 ,  NFKAPPAB65_01 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  TATAAA_TATA_01 ,  CEBP_01 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  ETS2_B ,  MGGAAGTG_GABP_B ,  GATA1_02 ,  RGAGGAARY_PU1_Q6 ,  CREL_01 ,  NFKB_Q6_01 ,  TGACATY_UNKNOWN ,  ETS1_B ,  COREBINDINGFACTOR_Q6 ,  NFKB_C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7

Cytogenetic Map:

5q31.1

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