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QuickView for interleukin 18 (gene)


Gene Symbol:
IL18 Homo sapiens Homo sapiens
Full name:
interleukin 18
Synonyms:
IGIF, IL-18, IL-1g, IL1F4, interleukin-18, IFN-gamma-inducing factor, IL-1 gamma, iboctadekin, interleukin 18 (interferon-gamma-inducing factor), interleukin-1 gamma
Genomic Location:
Chr 11: 111519186-111540050
Description:
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 11
11q23.1





GO Molecular Function

interleukin-18 receptor binding | signaling receptor binding | cytokine receptor binding | molecular function regulator | protein binding | receptor regulator activity | receptor ligand activity | cytokine activity

GO Biological Process

positive regulation of immune response | positive regulation of smooth muscle cell proliferation | regulation of T cell mediated immunity | adaptive immune response | granulocyte macrophage colony-stimulating factor production | positive regulation of macromolecule biosynthetic process | response to cytokine | interleukin-2 biosynthetic process | neutrophil activation | response to lipopolysaccharide | intracellular signal transduction | positive regulation of DNA-binding transcription factor activity | positive regulation of peptidyl-tyrosine phosphorylation | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | positive regulation of lymphocyte activation | regulation of T cell differentiation | defense response | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | blood vessel morphogenesis | positive regulation of T cell differentiation | positive regulation of cellular biosynthetic process | cellular process | positive regulation of immune effector process | positive regulation of adaptive immune response | T-helper 1 type immune response | positive regulation of protein kinase activity | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | positive regulation of natural killer cell proliferation | regulation of cell differentiation | positive regulation of granulocyte macrophage colony-stimulating factor production | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | leukocyte activation | cellular response to lipid | regulation of metabolic process | positive regulation of activated T cell proliferation | cellular response to molecule of bacterial origin | type 2 immune response | positive regulation of interferon-gamma production | regulation of type 2 immune response | positive regulation of cellular protein metabolic process | regulation of natural killer cell activation | positive regulation of T cell cytokine production | MAPK cascade | T cell cytokine production | positive regulation of interleukin-17 production | response to stimulus | vasculature development | positive regulation of NIK/NF-kappaB signaling | positive regulation of cold-induced thermogenesis | regulation of macrophage derived foam cell differentiation | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | regulation of CD4-positive, alpha-beta T cell activation | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | positive regulation of JAK-STAT cascade | positive regulation of lymphocyte proliferation | regulation of cell proliferation | sterol homeostasis | tube morphogenesis | positive regulation of cell-cell adhesion | cholesterol homeostasis | positive regulation of cell activation | positive regulation of natural killer cell activation | cardiovascular system development | response to molecule of bacterial origin | interleukin-2 production | positive regulation of T cell activation | cellular response to organic cyclic compound | positive regulation of RNA biosynthetic process | protein modification process | regulation of cell adhesion | macromolecule modification | cell-cell signaling | activation of protein kinase activity | molecular function regulator | regulation of lymphocyte differentiation | blood vessel development | interleukin-18-mediated signaling pathway | regulation of nucleic acid-templated transcription | positive regulation of mononuclear cell proliferation | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of T-helper 1 cell cytokine production | multicellular organism development | positive regulation of lymphocyte differentiation | phosphorus metabolic process | positive regulation of inflammatory response | leukocyte mediated immunity | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of phosphorylation | regulation of CD4-positive, alpha-beta T cell differentiation | regulation of T cell activation | positive regulation of alpha-beta T cell differentiation | regulation of activated T cell proliferation | regulation of gene expression | cell killing | response to lipid | interferon-gamma biosynthetic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of alpha-beta T cell proliferation | regulation of lymphocyte activation | sleep | cellular response to interleukin-18 | CD4-positive, alpha-beta T cell cytokine production | regulation of nitrogen compound metabolic process | positive regulation of STAT cascade | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | positive regulation of T-helper 2 cell differentiation | regulation of transcription by RNA polymerase II | negative regulation of myoblast differentiation | positive regulation of cell differentiation | activation of protein kinase B activity | regulation of T cell cytokine production | cellular response to cytokine stimulus | cell proliferation | biosynthetic process | positive regulation of NK T cell activation | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | angiogenesis | phosphorylation | triglyceride homeostasis | interleukin-6 production | cytokine production involved in immune response | protein phosphorylation | phosphate-containing compound metabolic process | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of natural killer cell proliferation | positive regulation of NK T cell proliferation | positive regulation of tyrosine phosphorylation of STAT protein | regulation of alpha-beta T cell differentiation | positive regulation of macrophage derived foam cell differentiation | inflammatory response | T cell mediated immunity | regulation of cytokine production involved in immune response | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | lymphocyte activation | positive regulation of molecular function | cytokine production | regulation of signaling receptor activity | receptor regulator activity | protein metabolic process | positive regulation of type 2 immune response | positive regulation of T-helper cell differentiation | positive regulation of protein modification process | response to organic substance | regulation of hemopoiesis | chemokine production | chemokine biosynthetic process | regulation of JAK-STAT cascade | regulation of kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of myoblast differentiation | positive regulation of cytokine production involved in immune response | regulation of tissue remodeling | chemical homeostasis | receptor ligand activity | immune response | leukocyte mediated cytotoxicity | cytokine activity | organic substance metabolic process | positive regulation of T-helper 1 type immune response | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | positive regulation of kinase activity | regulation of phosphate metabolic process | response to interleukin-18 | positive regulation of cytokine production | cell activation | positive regulation of T cell mediated immunity | natural killer cell mediated immunity | anatomical structure formation involved in morphogenesis | regulation of T-helper cell differentiation | regulation of cell communication | natural killer cell activation | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | regulation of T cell proliferation | positive regulation of CD4-positive, alpha-beta T cell differentiation | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | anatomical structure morphogenesis | response to biotic stimulus | positive regulation of tissue remodeling | regulation of developmental process | cytokine biosynthetic process | interleukin-13 biosynthetic process | developmental process | positive regulation of alpha-beta T cell activation | natural killer cell mediated cytotoxicity | cellular protein modification process | acylglycerol homeostasis | tube development | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | innate immune response | positive regulation of nucleic acid-templated transcription | granulocyte macrophage colony-stimulating factor biosynthetic process | positive regulation of transcription by RNA polymerase II | cytokine metabolic process | interleukin-13 production | T-helper 1 cell cytokine production | positive regulation of metabolic process | regulation of interferon-gamma production | immune system process | cellular metabolic process | cellular response to organic substance | chemokine metabolic process | regulation of smooth muscle cell proliferation | positive regulation of CD4-positive, alpha-beta T cell activation | circulatory system development | regulation of inflammatory response | positive regulation of leukocyte cell-cell adhesion | lipid homeostasis | negative regulation of cell differentiation | response to other organism | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | positive regulation of gene expression | interferon-gamma production | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

cell | cytoplasm | extracellular region | extracellular space | cytosol | intracellular