QuickView for ip3 receptor (gene)

Gene Symbol:

ITPR3 Homo sapiens

Full name:

inositol 1,4,5-trisphosphate receptor type 3

Synonyms:

IP3R, IP3R3, inositol 1,4,5-trisphosphate receptor type 3, IP3 receptor, inositol 1,4,5-triphosphate receptor, type 3, insP3R3, type 3 InsP3 receptor

Genomic Location:

Chr 6: 33697139-33772329

Description:

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role ...

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This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PAX4_04 ,  OCT1_05 ,  OCT1_B ,  RYTTCCTG_ETS2_B ,  OCT1_01 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  POU3F2_01 ,  TTGCWCAAY_CEBPB_02 ,  SYATTGTG_UNKNOWN ,  STAT6_02 ,  GCANCTGNY_MYOD_Q6 ,  SREBP1_Q6 ,  GR_Q6_01 ,  OCT_C ,  CEBPDELTA_Q6 ,  OCT1_Q6 ,  CEBPB_01 ,  DBP_Q6 ,  CAGGTA_AREB6_01 ,  CAGGTG_E12_Q6 ,  LHX3_01 ,  NKX62_Q2 ,  ZID_01 ,  MYOD_Q6 ,  TGCCTTA_MIR124A ,  TGCTGAY_UNKNOWN ,  CEBPB_02 ,  NERF_Q2 ,  S8_01 ,  MGGAAGTG_GABP_B ,  FOXO1_01 ,  TGTTTGY_HNF3_Q6 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  GR_01 ,  WGGAATGY_TEF1_Q6 ,  AP4_Q6_01 ,  CART1_01 ,  YTAATTAA_LHX3_01 ,  SREBP_Q3 ,  ICSBP_Q6 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  ZF5_B ,  PAX4_03 ,  ETS1_B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u

Cytogenetic Map:

6p21.31

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