QuickView for islet amyloid polypeptide (gene)
- Gene Symbol:
- IAPP
Homo sapiens - Full name:
- islet amyloid polypeptide
- Synonyms:
- DAP, IAP, islet amyloid polypeptide, Islet amyloid polypeptide (diabetes-associated peptide; amylin), amylin, diabetes-associated peptide, insulinoma amyloid peptide
- Genomic Location:
- Chr 12: 21417085-21423683
- Description:
-
This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein a...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
12p12.1
GO Molecular Function
peptide binding | amyloid-beta binding | signaling receptor binding | hormone activity | molecular function regulator | amide binding | identical protein binding | protein binding | receptor regulator activity | receptor ligand activity
GO Biological Process
regulation of supramolecular fiber organization | protein homooligomerization | positive regulation of apoptotic process | regulation of programmed cell death | negative regulation of protein homooligomerization | negative regulation of cellular process | negative regulation of tissue remodeling | negative regulation of mitochondrion organization | cellular chemical homeostasis | positive regulation of phosphate metabolic process | regulation of protein oligomerization | regulation of organelle organization | regulation of bone remodeling | cellular process | cellular homeostasis | positive regulation of protein kinase A signaling | positive regulation of nitrogen compound metabolic process | regulation of cell differentiation | regulation of protein kinase B signaling | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of protein complex assembly | regulation of cytosolic calcium ion concentration | positive regulation of cellular protein metabolic process | negative regulation of bone resorption | cellular component organization | calcium ion homeostasis | response to stimulus | positive regulation of protein metabolic process | programmed cell death | negative regulation of protein oligomerization | hormone activity | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | cellular component assembly | cell-cell signaling | molecular function regulator | metal ion homeostasis | apoptotic process | nitrogen compound metabolic process | regulation of signal transduction | regulation of MAPK cascade | negative regulation of amyloid fibril formation | protein complex oligomerization | positive regulation of protein kinase B signaling | regulation of phosphorylation | amylin receptor signaling pathway | nervous system process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | sensory perception of pain | regulation of cellular protein metabolic process | eating behavior | cation homeostasis | regulation of mitochondrion organization | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | regulation of signaling receptor activity | receptor regulator activity | protein-containing complex assembly | regulation of protein homooligomerization | protein metabolic process | positive regulation of protein modification process | regulation of intracellular signal transduction | metabolic process | regulation of amyloid fibril formation | regulation of bone resorption | regulation of tissue remodeling | chemical homeostasis | behavior | positive regulation of cell death | receptor ligand activity | negative regulation of protein complex assembly | organic substance metabolic process | cell death | positive regulation of programmed cell death | ion homeostasis | regulation of phosphate metabolic process | positive regulation of MAPK cascade | regulation of protein kinase A signaling | negative regulation of protein metabolic process | sensory perception | regulation of cell communication | signaling | feeding behavior | positive regulation of phosphorylation | cellular protein metabolic process | regulation of developmental process | cellular metal ion homeostasis | negative regulation of supramolecular fiber organization | negative regulation of bone remodeling | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | divalent inorganic cation homeostasis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
somatodendritic compartment | cell body | cell | neuronal cell body | extracellular region | extracellular space
