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QuickView for isothipendyl (compound)

Summary
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PubChem

PubChem Compound 14668

PubChem Compound 14668

Name:	isothipendyl
PubChem Compound ID:	14668
Molecular formula:	C₁₆H₂₀ClN₃S
Molecular weight:	321.869 g/mol
Synonyms:	10-(2-Dimethylaminopropyl)-9-thia-1,10-diazaanthracene hydrochloride; 10H-Pyrido(3,2-b)(1,4)benzothiazine-10-ethanamine, N,N,2-trimethyl-, monohydrochloride (9CI); Adantol; Udantol hydrochloride; Isothipendyl hydrochloride (JAN); NSC 169186; 10-(2-Dimethylamino-2-methylethyl)-10H-pyrido(3,2-b)(1,4)benzothiazine hydrochloride; 10-(2-Dimethylaminopropyl)-10H-pyrido(3,2-b)(1,4)benzothiazine hydrochloride; Theruhistin; D01143. show more » 10-(2-Dimethylaminopropyl)-9-thia-1,10-diazaanthracene hydrochloride; 10H-Pyrido(3,2-b)(1,4)benzothiazine-10-ethanamine, N,N,2-trimethyl-, monohydrochloride (9CI); Adantol; Udantol hydrochloride; Isothipendyl hydrochloride (JAN); NSC 169186; 10-(2-Dimethylamino-2-methylethyl)-10H-pyrido(3,2-b)(1,4)benzothiazine hydrochloride; 10-(2-Dimethylaminopropyl)-10H-pyrido(3,2-b)(1,4)benzothiazine hydrochloride; Theruhistin; D01143; Isothipendyl hydrochloride; Theruhistin hydrochloride; Isothipendyl monohydrochloride; EINECS 252-022-7; 10-(2-(Dimethylamino)propyl)-10H-pyrido(3,2-b)(1,4)benzothiazine hydrochloride; Isothipendyl hydrochloride [JAN]; EINECS 214-957-9; 10-(2-Dimethylaminopropyl)-1-azaphenothiazine hydrochloride; 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(2-(dimethylamino)propyl)-, monohydrochloride (8CI); N-Dimethylaminoisopropylthiophenylpyridylamine hydrochloride; Andantol; 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(2-dimethylamino-2-methylethyl)-, hydrochloride; Nilergex hydrochloride; 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(2-(dimethylamino)propyl)-, monohydrochloride; 1225-60-1; Dimethylamino-isopropyl-thiophenyl-pyridylamin hydrochlorid [German]; 10-(2-Dimethylaminopropyl)-(1)-4-azaphenthiazin hydrochlorid [German]; Andantol (TN); Adanton hydrochloride; 34433-15-3 show less «

DrugBank

Identification

Name:	isothipendyl
Name (isomeric):	DB08802
Drug Type:	small molecule
Synonyms:	Isothipendylum
Brand:	Andanton, Odantol, Nilergex, Udantol, Actapront
Category:	Histamine Antagonists, Anti-Allergic Agents, Antipruritic Agents
CAS number:	482-15-5

Pharmacology

Indication:	For the topical treatment of itching associated with allergic reactions.
Pharmacology:	Isothipendyl, an azaphenothiazine derivative, competitively binds to histamine (H1) receptors, resulting in inhibition of the pharmacological effects of histamines. It also has some sedative, anticholinergic and antiserotoninergic effects.
Mechanism of Action:	Isothipendyl is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Affected organisms:	Humans and other mammals

Targets

Histamine H1 receptor