Name: | Ketamine |
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PubChem Compound ID: | 15851 |
Description: | A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors. |
Molecular formula: | C13H17Cl2NO |
Molecular weight: | 274.186 g/mol |
Synonyms: |
Ketavet; Ketalar (TN); Ketaset; EINECS 217-484-6; Ketalar; HSDB 2180; 100477-73-4; CN-52,372-2; Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, hydrochloride, (+-)-; 96448-41-8.
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Name: | Ketamine |
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Name (isomeric): | DB01221 |
Drug Type: | small molecule |
Description: | A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors. |
Synonyms: |
Ketamine Base; (S)-Ketamine; Ketamine HCL; (S)-(-)-Ketamine; l-Ketamine; (-)-Ketamine; CI 581 base
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Brand: | Ketalar base, Ketanest, Esketamine, CLSTA 20, Ketalar, Ketolar, Ketaject |
Category: | General Anesthetics, Analgesics, Anesthetics, Dissociative, Excitatory Amino Acid Antagonists |
CAS number: | 6740-88-1 |
Indication: | For use as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. |
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Pharmacology: |
Ketamine is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone, cardiovascular and respiratory stimulation, and occasionally a transient and minimal respiratory depression. Ketamine is indicated as the sole anesth...
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Mechanism of Action: |
Ketamine has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some stimulation of the cardiocascular system. Ketamine has been reported to produce general as well as local anaesthesia. It interacts with N-methyl-D-aspartate (NMDA) receptors, opioid ...
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Absorption: | Rapidly absorbed following parenteral administration. |
Biotransformation: | Hepatic. |
Half Life: | 2.5-3 hours. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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