QuickView for kindlin 3 (gene)

Gene Symbol:

FERMT3 Homo sapiens

Full name:

fermitin family member 3

Synonyms:

KIND3, MIG-2, MIG2B, UNC112C, URP2, URP2SF, fermitin family homolog 3, MIG2-like protein, UNC-112 related protein 2, kindlin 3, unc-112-related protein 2

Genomic Location:

Chr 11: 63730782-63747939

Description:

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane sk...

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Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AP1_C ,  TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  PEA3_Q6 ,  AP1_Q6 ,  GATAAGR_GATA_C ,  GGGAGGRR_MAZ_Q6 ,  AP1_Q6_01 ,  GGGCGGR_SP1_Q6 ,  CCCNNGGGAR_OLF1_01 ,  AP1_Q4 ,  CTGCAGY_UNKNOWN ,  ELK1_02

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Cytogenetic Map:

11q13.1

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