QuickView for kleisin (gene)

Gene Symbol:

RAD21 Homo sapiens

Full name:

RAD21 cohesin complex component

Synonyms:

CDLS4, HR21, HRAD21, MCD1, NXP1, SCC1, hHR21, double-strand-break repair protein rad21 homolog, NXP-1, RAD21 homolog, SCC1 homolog, kleisin, nuclear matrix protein 1, protein involved in DNA double-strand break repair, sister chromatid cohesion 1

Genomic Location:

Chr 8: 117927355-117956182

Description:

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of...

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The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  RTAAACA_FREAC2_01 ,  ACACTCC_MIR122A ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  HFH3_01 ,  AAAYWAACM_HFH4_01 ,  HFH1_01 ,  GCCATNTTG_YY1_Q6 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  GGGAGGRR_MAZ_Q6 ,  TCTGATA_MIR361 ,  YY1_Q6 ,  CATGTAA_MIR496 ,  TGCGCANK_UNKNOWN ,  AP2_Q6_01 ,  GGCNKCCATNK_UNKNOWN ,  TGTTTGY_HNF3_Q6 ,  HFH8_01 ,  GGCNNMSMYNTTG_UNKNOWN ,  FREAC2_01 ,  TTGTTT_FOXO4_01 ,  YY1_02 ,  RCGCANGCGY_NRF1_Q6 ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

8q24.11

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