QuickView for lactadherin (gene)

Gene Symbol:

MFGE8 Homo sapiens

Full name:

milk fat globule-EGF factor 8 protein

Synonyms:

BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47, lactadherin, O-acetyl disialoganglioside synthase, breast epithelial antigen BA46, medin, sperm associated antigen 10, sperm surface protein hP47

Genomic Location:

Chr 15: 87242920-87257614

Description:

This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed ...

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This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTANTCA_UNKNOWN ,  MEF2_02 ,  GGATTA_PITX2_Q2 ,  GGGCGGR_SP1_Q6 ,  CTTTAAR_UNKNOWN ,  YCATTAA_UNKNOWN ,  TTGTTT_FOXO4_01 ,  MEF2_03 ,  AP1_Q2 ,  MEF2_Q6_01

Cytogenetic Map:

15q26.1

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