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QuickView for lidocaine (compound)


PubChem
Name: Lidocaine
PubChem Compound ID: 11436229
Description: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.
Molecular formula: C14H22N2O
Molecular weight: 233.338 g/mol
DrugBank
Identification
Name: Lidocaine
Name (isomeric): DB00281
Drug Type: small molecule
Description: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.
Synonyms:
L-Caine; Dilocaine
Brand: Xylocaine-MPF with Glucose, Emla, Xylocaine Dental Ointment, Xylocaine, Solarcaine, Isicaina, Duncaine, Xylocaine-MPF, Xylocaine Endotracheal, Solcain, Rocephin Kit, Xylocard, Lignocaine, Lidoject-1, Lidoject-2, Solarcaine aloe extra burn relief cream, Xylocaine Viscous, Octocaine-50, Octocaine, Xylocaine Test Dose, Esracaine, Maricaine, After Burn Gel, Dalcaine, Leostesin, After Burn Spray, Lanabiotic, Alphacaine, Gravocain, Anestacon, After Burn Double Strength Spray, DermaFlex, Lidoderm, Anestacon Jelly, Octocaine-100, Xylocaine 5% Spinal, Norwood Sunburn Spray, Zingo, Cappicaine, Zilactin-L, After Burn Double Strength Gel
Brand name mixture:
Jamshidi Menghini Soft Tissue Biopsy Tray(Lidocaine Hydrochloride + Povidone-Iodine + Sodium Chloride), Caustinerf(Camphor + Chlorophenol + Lidocaine + Paraformaldehyde), Octocaine 100 Needleject Inj(Epinephrine + Lidocaine Hydrochloride), Polysporin Antibiotic Burn Cream(Gramicidin + Lidocaine Hydrochloride + Polymyxin B (Polymyxin B Sulfate)),...
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Category: Antiarrhythmic Agents, Anesthetics, Anti-Arrhythmia Agents, Anesthetics, Local
CAS number: 137-58-6
Pharmacology
Indication: For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.
Pharmacology:
Lidocaine is an anesthetic agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhy...
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Mechanism of Action:
Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. Lidocaine alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation. ...
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Absorption: Information derived from diverse formulations, concentrations and usages reveals that lidocaine is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent.
Protein binding: 60-80%
Biotransformation: Primarily hepatic.
Route of elimination: Lidocaine and its metabolites are excreted by the kidneys.
Half Life: 109 minutes
Clearance: 0.64 +/- 0.18 L/min
Toxicity: The oral LD 50 of lidocaine HCl in non-fasted female rats is 459 (346-773) mg/kg (as the salt) and 214 (159-324) mg/kg (as the salt) in fasted female rats. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
CimetidineIncreases the effect and toxicity of lidocaine
BisoprololThe beta-blocker, bisoprolol, may increase the effect and toxicity of lidocaine.
TizanidineLidocaine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
TramadolLidocaine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Lidocaine may decrease the effect of Tramadol by decreasing active metabolite production.
TamoxifenLidocaine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
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