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QuickView for lisinopril (compound)


PubChem
Name: Lisinopril
PubChem Compound ID: 5362118
Description: One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.
Molecular formula: C21H35N3O7
Molecular weight: 441.519 g/mol
Synonyms:
CAS-83915-83-7; Lisinopril; Prinivil (TN); Prinivil; Lisinopril dihydrate; D00362; Prinzide; L-Proline, 1-(N(sup 2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-, dihydrate, (S)-; 76547-98-3; 82009-35-6.
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DrugBank
Identification
Name: Lisinopril
Name (isomeric): DB00722
Drug Type: small molecule
Description: One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure.
Brand: Acercomp, Inhibril, Sinopril, Prinivil, Noperten, Lisinopril Dihydrate, Lysinopril, Presiten, Zestril, Linopril, Lisipril
Brand name mixture: Zestoretic Tab 20/12.5mg(lisinopril + hydrochlorothiazide), Zestoretic Tab 10/12.5mg(lisinopril + hydrochlorothiazide), Lisinopril Comp(lisinopril + hydrochlorothiazide), Zestoretic Tab 20/25mg(lisinopril + hydrochlorothiazide), Prinzide(lisinopril + hydrochlorothiazide)
Category: Angiotensin-converting Enzyme Inhibitors, Antihypertensive Agents
CAS number: 83915-83-7
Pharmacology
Indication: For the treatment of hypertension and symptomatic congestive heart failure. May be used in conjunction with thrombolytic agents, aspirin and/or β-blockers to improve survival in hemodynamically stable individuals following myocardial infarction. May be used to slow the progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.
Pharmacology:
Lisinopril is an orally active ACE inhibitor that antagonizes the effect of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the ...
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Mechanism of Action:
There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which has a lower molecular mass and is thought to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE has two functionally active domains, N and C, w...
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Absorption: Approximately 25%, but widely variable between individuals (6 to 60%) in all doses tested (5-80 mg); absorption is unaffected by food
Protein binding: Lisinopril does not appear to be bound to serum proteins other than ACE.
Biotransformation: Does not undergo metabolism, excreted unchanged in urine.
Route of elimination: Lisinopril does not undergo metabolism and is excreted unchanged entirely in the urine.
Half Life: Effective half life of accumulation following multiple dosing is 12 hours.
Clearance: 10 L/h [child weighting 30 kg receiving doses of 0.1 to 0.2 mg/kg]
Toxicity: Symptoms of overdose include severe hypotension, electrolyte disturbances, and renal failure. LD50= 2000 mg/kg(orally in rat). Most frequent adverse effects include headache, dizziness, cough, fatigue and diarrhea.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Lisinopril decreases the excretion of potassium. Salt substitutes containing potassium increase the risk of hyperkalemia.
High salt intake may attenuate the antihypertensive effect of lisinopril.
Take without regard to meals.
Herbs that may attenuate the antihypertensive effect of lisinopril include: bayberry, blue cohash, cayenne, ephedra, ginger, ginseng (American), kola and licorice.
Drug interaction:
LithiumThe ACE inhibitor increases serum levels of lithium
TizanidineTizanidine increases the risk of hypotension with the ACE inhibitor
TobramycinIncreased risk of nephrotoxicity
SpironolactoneIncreased risk of hyperkalemia
PotassiumIncreased risk of hyperkalemia
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