Name: | Loratadine |
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PubChem Compound ID: | 3957 |
Description: | A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness. |
Molecular formula: | C22H23ClN2O2 |
Molecular weight: | 382.883 g/mol |
Synonyms: |
Clarityne; Claritin; NINDS_000792; Lorastine; Claratyne Cold; Loracert; Talorat Dy; Loratadine; Polaratyne; KBio1_000792.
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Name: | Loratadine |
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Name (isomeric): | DB00455 |
Drug Type: | small molecule |
Description: | A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness. |
Synonyms: |
Loratadina [Spanish]; Loratadinum [Latin]
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Brand: | Alarin, Sinhistan Dy, Pylor, Clarityn, Versal, Lorantis, Lomilan, Loracert, Rhinase, Loradif, Lergy, Zeos, Claritin-D, Sanelor, Restamine, Loradex, Fristamin, Loranox, Clarityne, Bonalerg, Lowadina, Lorfast, Rinomex, Claritin Reditabs, Loratyne, Allertidin, Talorat Dy, Clarinase, Lesidas, Bedix Loratadina, Claritine, Sohotin, Lertamine, Polaratyne, Alerpriv, Roletra, Tadine, Alavert, Claritin, Optimin, Clarinase Reperabs, Lisino, Lorastine, Nularef, Loraver, Biloina, Sensibit, Claratyne, Histaloran, Civeran, Velodan, Loritine, Aerotina |
Brand name mixture: | Liberator(Loratadine + Pseudoephedrine Sulfate), Chlor-Tripolon ND SRT(Loratadine + Pseudoephedrine Sulfate), Claritin Allergy + Sinus Extra Strength(Loratadine + Pseudoephedrine Sulfate) |
Category: | Antihistamines, Antipruritics, Anti-Allergic Agents, Histamine H1 Antagonists, Non-Sedating |
CAS number: | 79794-75-5 |
Indication: | A self-medication that is used alone or in combination with pseudoephedrine sulfate for the symptomatic relief of seasonal allergic rhinitis. Also used for the symptomatic relief of pruritus, erythema, and urticaria associated with chronic idiopathic urticaria in patients (not for children under 6 unless directed by a clincian). |
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Pharmacology: |
Loratadine is a long acting second generation antihistamine that is similar in structure to cyproheptadine and azatadine. The pharmacology of loratadine is similar to other antihistamines, but unlike other H1-blockers, loratidine is shown to exhibit competitive, specific, and selective antagonism of H1 receptors. The exact mec...
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Mechanism of Action: |
Loratadine competes with free histamine and exhibits specific, selective peripheral H1 antagonistic activity. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Loratadine has low affinity for cholinergic recept...
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Absorption: | Rapidly absorbed following oral administration (40% bioavailability) |
Protein binding: | 97-99% |
Biotransformation: | Hepatic |
Half Life: | 8.4 hours |
Toxicity: | somnolence, tachycardia, and headache LD50=mg/kg (orally in rat) |
Affected organisms: | Humans and other mammals |
Food interaction: |
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