QuickView for lrp5 (gene)

Gene Symbol:

LRP5 Homo sapiens

Full name:

LDL receptor related protein 5

Synonyms:

BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2, low-density lipoprotein receptor-related protein 5, low density lipoprotein receptor-related protein 5, low density lipoprotein receptor-related protein 7

Genomic Location:

Chr 11: 67836684-67973319

Description:

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes me...

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This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  E12_Q6 ,  PR_Q2 ,  IRF1_01 ,  RTAAACA_FREAC2_01 ,  HNF3ALPHA_Q6 ,  STAT1_02 ,  RYTTCCTG_ETS2_B ,  YTATTTTNR_MEF2_02 ,  SRF_Q6 ,  GCANCTGNY_MYOD_Q6 ,  SRY_01 ,  STAT6_01 ,  FAC1_01 ,  STAT1_03 ,  TGACCTY_ERR1_Q2 ,  AML1_01 ,  CTTTGTA_MIR524 ,  YAATNRNNNYNATT_UNKNOWN ,  MYCMAX_02 ,  PAX4_02 ,  FOXO3_01 ,  RP58_01 ,  CAGGTG_E12_Q6 ,  ETS2_B ,  NKX62_Q2 ,  STAT5A_03 ,  CTTTAAR_UNKNOWN ,  GCCNNNWTAAR_UNKNOWN ,  AREB6_03 ,  AATGTGA_MIR23A_MIR23B ,  AML1_Q6 ,  FREAC2_01 ,  CETS1P54_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  AAAYRNCTG_UNKNOWN ,  MYOGENIN_Q6 ,  WTTGKCTG_UNKNOWN ,  HEN1_02 ,  TEF_Q6 ,  CTGCAGY_UNKNOWN ,  T3R_Q6 ,  TAL1BETAITF2_01 ,  TCCATTKW_UNKNOWN ,  STAT1_01 ,  CTTTGT_LEF1_Q2 ,  ER_Q6_01 ,  CAGCTG_AP4_Q5 ,  FOXM1_01 ,  SRY_02 ,  PAX4_03 ,  USF_02 ,  COREBINDINGFACTOR_Q6 ,  FOXO4_02 ,  SRF_C ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-375

Cytogenetic Map:

11q13.2

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