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QuickView for matrix metalloproteinase 2 (gene)


Gene Symbol:
Mmp2 Mus musculus Mus musculus
Full name:
matrix metallopeptidase 2
Synonyms:
Clg4a, GelA, MMP-2, 72 kDa type IV collagenase, 72 kDa gelatinase, 72kD gelatinase, 72kD type IV collagenase, 72kDa gelatinase, 72kDa type IV collagenase, gelatinase A, matrix metalloproteinase 2
Genomic Location:
Chr 8: 95351227-95377319
Description:
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that hydrolyzes coll...
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_008610
XM_006530751
Protein Names
Q3UG07
P33434



GO Molecular Function

metallopeptidase activity | cation binding | metalloendopeptidase activity | hydrolase activity | catalytic activity | serine hydrolase activity | ion binding | protein binding | zinc ion binding | serine-type endopeptidase activity | transition metal ion binding | serine-type peptidase activity | endopeptidase activity | metal ion binding | peptidase activity | fibronectin binding

GO Biological Process

positive regulation of immune response | positive regulation of smooth muscle cell proliferation | metallopeptidase activity | regulation of blood vessel diameter | positive regulation of locomotion | cell motility | developmental process involved in reproduction | ovarian follicle development | positive regulation of apoptotic process | proteolysis | regulation of localization | morphogenesis of an epithelium | gonad development | regulation of programmed cell death | female gonad development | regulation of immune system process | response to hormone | negative regulation of cellular process | cell differentiation | nervous system development | response to drug | neurogenesis | positive regulation of cellular component movement | generation of neurons | response to antibiotic | blood vessel morphogenesis | positive regulation of vascular smooth muscle cell proliferation | cellular process | regulation of cell motility | localization | tissue remodeling | metalloendopeptidase activity | neuron development | reproductive system development | response to estradiol | female pregnancy | response to hypoxia | response to inorganic substance | tissue development | regeneration | response to hydrogen peroxide | regulation of immune response | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | head morphogenesis | catabolic process | trabecula morphogenesis | epithelium development | cellular response to organonitrogen compound | cellular component organization | prostate gland epithelium morphogenesis | urogenital system development | development of primary sexual characteristics | head development | response to stimulus | vasculature development | positive regulation of innate immune response | collagen catabolic process | positive regulation of immune system process | negative regulation of cell adhesion | regulation of blood vessel size | gland morphogenesis | response to stress | regulation of cell proliferation | tube morphogenesis | regulation of blood circulation | development of primary female sexual characteristics | reproduction | cardiovascular system development | cellular response to organic cyclic compound | blood circulation | regulation of cell adhesion | blood vessel development | locomotion | response to nitrogen compound | cellular response to hormone stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | multicellular organism development | cell migration | response to amino acid | axon development | cellular response to stress | response to lipid | response to axon injury | animal organ morphogenesis | intramembranous ossification | regulation of cell migration | regulation of cellular component movement | response to oxidative stress | bone trabecula formation | positive regulation of cell migration | neuron projection regeneration | angiogenesis | response to toxic substance | cellular response to amino acid stimulus | response to estrogen | skeletal system morphogenesis | peripheral nervous system axon regeneration | heart development | positive regulation of cell proliferation | regulation of locomotion | regulation of tube size | neuron differentiation | protein metabolic process | response to organic substance | gland development | regulation of innate immune response | tissue morphogenesis | response to wounding | response to mechanical stimulus | face morphogenesis | anatomical structure development | regulation of vasoconstriction | cell projection organization | metabolic process | developmental maturation | regulation of tube diameter | positive regulation of cell death | bone trabecula morphogenesis | neuron projection development | organic substance metabolic process | animal organ development | response to reactive oxygen species | positive regulation of programmed cell death | serine-type endopeptidase activity | prostate gland morphogenesis | serine-type peptidase activity | blood vessel maturation | anatomical structure formation involved in morphogenesis | cellular response to estradiol stimulus | response to organic cyclic compound | endopeptidase activity | cell development | anatomical structure morphogenesis | prostate gland development | collagen metabolic process | reproductive structure development | axon regeneration | developmental process | tube development | response to organonitrogen compound | embryo implantation | ossification | skeletal system development | negative regulation of vasoconstriction | body morphogenesis | peptidase activity | female sex differentiation | cellular response to organic substance | regulation of cell death | sex differentiation | regulation of smooth muscle cell proliferation | positive regulation of cell motility | positive regulation of blood vessel diameter | circulatory system development | aging | macromolecule metabolic process | multicellular organismal process | face development

GO Cellular Component

supramolecular fiber | intracellular membrane-bounded organelle | extracellular matrix | sarcomere | cell | myofibril | cytoplasm | intracellular organelle | contractile fiber | plasma membrane | mitochondrion | extracellular region | membrane-bounded organelle | nucleus | organelle | extracellular space | cell periphery | intracellular | membrane | supramolecular complex