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QuickView for mepyramine (compound)
PubChem
| Name: | Pyrilamine |
|---|---|
| PubChem Compound ID: | 449748 |
| Description: | A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies. |
| Molecular formula: | C17H23N3O |
| Molecular weight: | 284.385 g/mol |
| Synonyms: |
MOLI001592; MOLI000145
|
DrugBank
Identification
| Name: | Pyrilamine |
|---|---|
| Name (isomeric): | DB06691 |
| Drug Type: | small molecule |
| Description: | A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies. |
| Synonyms: |
pyrilamine
|
| Category: | Antihistamines, Histamine H1 Antagonists |
| CAS number: | 91-84-9 |
Pharmacology
| Indication: | Mepyramine is a first generation antihistamine used in treating allergies, ymptomatic relief of hypersensitivity reaction, and in pruritic skin disorders. |
|---|---|
| Mechanism of Action: |
Mepyramine is a histamine H1 receptor inverse agonist. It binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Mepyramine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in su...
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| Toxicity: | The signs and symptoms that are produced after the acute overdosage of Mepyramine include Convulsions, Coma, Ataxia, Hyperpyrexia, Tremor, Extrapyramidal effects, Excitement. |
Interactions
| Food interaction: |
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Targets
Enzymes
