QuickView for metabotropic glutamate receptor 5 (gene)

Gene Symbol:

GRM5 Homo sapiens

Full name:

glutamate metabotropic receptor 5

Synonyms:

GPRC1E, MGLUR5, PPP1R86, mGlu5, metabotropic glutamate receptor 5, glutamate receptor, metabotropic 5, protein phosphatase 1, regulatory subunit 86

Genomic Location:

Chr 11: 87880626-88420838

Description:

This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission ...

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This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  GGGACCA_MIR133A_MIR133B ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  ATGTACA_MIR493 ,  LHX3_01 ,  S8_01 ,  TTGCCAA_MIR182 ,  CHX10_01 ,  TTGTTT_FOXO4_01 ,  TEF_Q6 ,  TGCTTTG_MIR330

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-493-5p

Cytogenetic Map:

11q14.2-q14.3

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