Name: | Methionine |
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PubChem Compound ID: | 5460884 |
Description: | A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals. |
Molecular formula: | C5H10NO2S- |
Molecular weight: | 148.204 g/mol |
Synonyms: |
methioninate; methionine anion; 2-amino-4-(methylsulfanyl)butanoate; CHEBI:32644; met(-)
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Name: | Methionine |
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Name (isomeric): | DB00134 |
Drug Type: | small molecule |
Description: | A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals. |
Synonyms: |
2-Amino-4-(methylthio)butyric acid; L-(-)-Methionine; Methionine; g-Methylthio-a-aminobutyric acid; L-a-Amino-g-methylthiobutyric acid; (S)-2-Amino-4-(methylthio)butanoic acid; a-Amino-g-methylmercaptobutyric acid
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Brand: | Cymethion, Acimethin |
Category: | Micronutrient, Dietary supplement, Essential Amino Acids |
CAS number: | 63-68-3 |
Indication: | Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate. |
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Pharmacology: |
L-Methionine is a principle supplier of sulfur which prevents disorders of the hair, skin and nails; helps lower cholesterol levels by increasing the liver's production of lecithin; reduces liver fat and protects the kidneys; a natural chelating agent for heavy metals; regulates the formation of ammonia and creates ammonia-free urine which reduces ...
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Mechanism of Action: |
The mechanism of the possible anti-hepatotoxic activity of L-methionine is not entirely clear. It is thought that metabolism of high doses of acetaminophen in the liver lead to decreased levels of hepatic glutathione and increased oxidative stress. L-methionine is a precursor to L-cysteine. L-cysteine itself may have antioxidant activity. L-cystein...
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Absorption: | Absorbed from the lumen of the small intestine into the enterocytes by an active transport process. |
Biotransformation: | Hepatic |
Toxicity: | Doses of L-methionine of up to 250 mg daily are generally well tolerated. Higher doses may cause nausea, vomiting and headache. Healthy adults taking 8 grams of L-methionine daily for four days were found to have reduced serum folate levels and leucocytosis. Healthy adults taking 13.9 grams of L-methionine daily for five days were found to have changes in serum pH and potassium and increased urinary calcium excretion. Schizophrenic patients given 10 to 20 grams of L-methionine daily for two weeks developed functional psychoses. Single doses of 8 grams precipitated encephalopathy in patients with cirrhosis. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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