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QuickView for methionine (compound)

Name: Methionine
PubChem Compound ID: 5460884
Description: A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.
Molecular formula: C5H10NO2S-
Molecular weight: 148.204 g/mol
methioninate; methionine anion; 2-amino-4-(methylsulfanyl)butanoate; CHEBI:32644; met(-)
Name: Methionine
Name (isomeric): DB00134
Drug Type: small molecule
Description: A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.
2-Amino-4-(methylthio)butyric acid; L-(-)-Methionine; Methionine; g-Methylthio-a-aminobutyric acid; L-a-Amino-g-methylthiobutyric acid; (S)-2-Amino-4-(methylthio)butanoic acid; a-Amino-g-methylmercaptobutyric acid
Brand: Cymethion, Acimethin
Category: Micronutrient, Dietary supplement, Essential Amino Acids
CAS number: 63-68-3
Indication: Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate.
L-Methionine is a principle supplier of sulfur which prevents disorders of the hair, skin and nails; helps lower cholesterol levels by increasing the liver's production of lecithin; reduces liver fat and protects the kidneys; a natural chelating agent for heavy metals; regulates the formation of ammonia and creates ammonia-free urine which reduces ...
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Mechanism of Action:
The mechanism of the possible anti-hepatotoxic activity of L-methionine is not entirely clear. It is thought that metabolism of high doses of acetaminophen in the liver lead to decreased levels of hepatic glutathione and increased oxidative stress. L-methionine is a precursor to L-cysteine. L-cysteine itself may have antioxidant activity. L-cystein...
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Absorption: Absorbed from the lumen of the small intestine into the enterocytes by an active transport process.
Biotransformation: Hepatic
Toxicity: Doses of L-methionine of up to 250 mg daily are generally well tolerated. Higher doses may cause nausea, vomiting and headache. Healthy adults taking 8 grams of L-methionine daily for four days were found to have reduced serum folate levels and leucocytosis. Healthy adults taking 13.9 grams of L-methionine daily for five days were found to have changes in serum pH and potassium and increased urinary calcium excretion. Schizophrenic patients given 10 to 20 grams of L-methionine daily for two weeks developed functional psychoses. Single doses of 8 grams precipitated encephalopathy in patients with cirrhosis.
Affected organisms: Humans and other mammals
Food interaction:
Take with food.