Name: | Misoprostol |
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PubChem Compound ID: | 10548149 |
Description: | A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties. |
Molecular formula: | C22H38O5 |
Molecular weight: | 385.553 g/mol |
Name: | Misoprostol |
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Name (isomeric): | DB00929 |
Drug Type: | small molecule |
Description: | A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties. |
Synonyms: |
Misoprostolum [INN-Latin]
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Brand: | Arthrotec, Cytotec |
Category: | Oxytocics, Prostaglandins, Abortifacient Agents, Anti-Ulcer Agents, Abortifacient Agents, Nonsteroidal |
CAS number: | 59122-46-2 |
Indication: | Indicated for the treatment of ulceration (duodenal, gastric and NSAID induced) and prophylaxis for NSAID induced ulceration. Misoprostol is also indicated for other uses that are not approved in Canada, including the medical termination of an intrauterine pregnancy used alone or in combination with methotrexate,as well as the induction of labour in a selected population of pregnant women with unfavourable cervices. This indication is avoided in women with prior uterine surgery or cesarean surgery due to an increased risk of possible uterine rupture. Misoprostol is also used for the prevention or treatment of serious postpartum hemorrhage. |
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Pharmacology: |
Misoprostol is a prostaglandin E1 (PGE1) analogue used for the treatment and prevention of stomach ulcers. When administered, misoprostol stimulates increased secretion of the protective mucus that lines the gastrointestinal tract and increases mucosal blood flow, thereby increasing mucosal integrity. It is sometimes co-prescribed with non-steroida...
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Mechanism of Action: |
Misoprostol seems to inhibit gastric acid secretion by a direct action on the parietal cells through binding to the prostaglandin receptor. The activity of this receptor is mediated by G proteins which normally activate adenylate cyclase. The indirect inhibition of adenylate cyclase by Misoprostol may be dependent on guanosine-5’-triphosphate...
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Absorption: | Misoprostol is extensively absorbed. |
Protein binding: | 85% |
Biotransformation: | Rapidly de-esterified to misoprostol acid. The de-esterified metabolite undergoes further metabolism by beta and omega oxidation; oxidation is followed by reduction of the ketone to yield prostaglandin F analogs. |
Route of elimination: | After a single oral dose of misoprostol to nursing mothers, misoprostol acid was excreted in breast milk. |
Half Life: | 20-40 minutes |
Affected organisms: | Humans and other mammals |
Food interaction: |
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Drug interaction: |
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