QuickView for mitofusin 1 (gene)
- Gene Symbol:
- MFN1
Homo sapiens - Full name:
- mitofusin 1
- Synonyms:
- hfzo1, hfzo2, mitofusin-1, fzo homolog, mitochondrial transmembrane GTPase FZO-2, mitochondrial transmembrane GTPase Fzo-1, putative transmembrane GTPase, transmembrane GTPase MFN1
- Genomic Location:
- Chr 3: 180548174-180593708
- Description:
-
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
3q26.33
GO Molecular Function
guanyl ribonucleotide binding | ribonucleoside binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | protein binding | GTP binding | hydrolase activity, acting on acid anhydrides | nucleoside binding | purine ribonucleotide binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding
GO Biological Process
purine ribonucleotide metabolic process | organelle fusion | macroautophagy | mitochondrial membrane fusion | membrane fusion | membrane organization | cellular process | localization | mitochondrial fusion | nucleotide metabolic process | ribose phosphate metabolic process | nucleoside triphosphate metabolic process | ribonucleotide metabolic process | catabolic process | organelle localization | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | purine nucleotide metabolic process | cellular localization | cellular nitrogen compound metabolic process | purine nucleoside metabolic process | mitochondrion organization | nitrogen compound metabolic process | phosphorus metabolic process | organophosphate metabolic process | nucleoside metabolic process | small molecule metabolic process | nucleobase-containing small molecule metabolic process | mitochondrion localization | phosphate-containing compound metabolic process | autophagy | mitochondrial membrane organization | GTP metabolic process | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | organelle organization | carbohydrate derivative metabolic process | heterocycle metabolic process | cellular metabolic process
GO Cellular Component
integral component of organelle membrane | integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cell | organelle outer membrane | intrinsic component of membrane | cytoplasm | outer mitochondrial membrane protein complex | intracellular organelle | protein-containing complex | mitochondrion | intrinsic component of mitochondrial outer membrane | membrane-bounded organelle | organelle | mitochondrial outer membrane | mitochondrial envelope | outer membrane | integral component of mitochondrial membrane | mitochondrial membrane | intracellular | integral component of mitochondrial outer membrane | membrane
