QuickView for multiple endocrine neoplasia type 1 (gene)

Gene Symbol:

MEN1 Homo sapiens

Full name:

menin 1

Synonyms:

MEAI, SCG2, menin

Genomic Location:

Chr 11: 64327564-64335342

Description:

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two m...

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This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  HEB_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TNCATNTCCYR_UNKNOWN ,  CTGAGCC_MIR24

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-24

Cytogenetic Map:

11q13.1

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