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QuickView for multispecific organic anion transporter (compound)


Name: Multidrug Resistance-Associated Proteins
Description: A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
Synonyms:
Multidrug Resistance Associated Proteins; Multidrug Resistance Associated Protein; Multispecific Organic Anion Transport Proteins; Multidrug Resistance-Associated Protein; MOAT Protein; ATP Binding Cassette, Sub Family C Proteins; Multispecific Organic Anion Transporter; Resistance-Associated Protein, Multidrug; ATP-Binding Cassette, Sub-Family C Proteins