QuickView for myotrophin (gene)

Gene Symbol:

MTPN Homo sapiens

Full name:

myotrophin

Synonyms:

GCDP, V-1, myotrophin, granule cell differentiation protein, protein V-1

Genomic Location:

Chr 7: 135262049-135312604

Description:

The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morpho...

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The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATGCAGT_MIR217 ,  GABP_B ,  PU1_Q6 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  AACTGAC_MIR223 ,  CAGTGTT_MIR141_MIR200A ,  ATGTACA_MIR493 ,  AAGCAAT_MIR137 ,  AATGGAG_MIR136 ,  CTTTGTA_MIR524 ,  GGGYGTGNY_UNKNOWN ,  TTCYRGAA_UNKNOWN ,  TGCGCANK_UNKNOWN ,  TGCCTTA_MIR124A ,  ATTCTTT_MIR186 ,  ACCAAAG_MIR9 ,  MGGAAGTG_GABP_B ,  ATACTGT_MIR144 ,  CETS1P54_01 ,  ELK1_01 ,  TTGTTT_FOXO4_01 ,  SCGGAAGY_ELK1_02 ,  RGAGGAARY_PU1_Q6 ,  NRF2_01 ,  TGCTTTG_MIR330 ,  RCGCANGCGY_NRF1_Q6 ,  ELK1_02 ,  ETS1_B ,  ELF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-136 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-493-5p

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Cytogenetic Map:

7q33

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