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QuickView for n methylscopolamine (compound)


PubChem
Name: N-Methylscopolamine
PubChem Compound ID: 4120
Description: A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
Molecular formula: C18H24NO4+
Molecular weight: 318.388 g/mol
Synonyms:
Epoxymethamine bromide; Methoscopylamine bromide; nsc61809; (-)-Tropate(ester); Nutrop; Neo-Avagal; Methylscopolamine bromide; Epoxytropine tropate methylbromide; (-)-Scopolamine methyl bromide; 1.alpha.-H,5.alpha.H-Tropanium, 6.beta., 7.beta.-epoxy-3.alpha.-hydroxy-8-methyl-, bromide, (-)-tropate.
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DrugBank
Identification
Name: N-Methylscopolamine
Name (isomeric): DB00462
Drug Type: small molecule
Description: A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
Synonyms:
Methylscopolamine Bromide; Scopolamine Methobromide; Scopolamin Methylbromide; Epoxymethamine Bromide; Methoscopylamine Bromide; N-Methylscopolamine Methylsulfate; Epoxytropine Tropate Methylbromide; Methscopolamine Methylbromide; Hyoscine Methobromide; Methylscopolamine Hydrobromide.
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Brand: Holopon, Proscomide, Restropin, Mescopil, Pamine, Transderm Scop, Diopal, Blocan, Daipin, Ampyrox, Nutrop, Neo-Avagal, Paraspan
Brand name mixture:
Neosol M Aquadrops(methscopolamine bromide + neomycin), Scour solution coop(methscopolamine bromide + neomycin), Neomix-pamine Scour Bolus(methscopolamine bromide + neomycin sulfate), Scour solution(methscopolamine bromide + neomycin), Neomix-pamine Solution(methscopolamine bromide + neomycin sulfate), Biosol-M-Aquadrops liq(methscopolamine brom...
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Category: Parasympatholytics, Anticholinergic Agents, Antispasmodics
CAS number: 155-41-9
Pharmacology
Indication: Used as adjunctive therapy for the treatment of peptic ulcer. Also used to treat nausea and vomiting due to motion sickness.
Pharmacology:
Methscopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Methscopolamine has many uses including the prevention of motion sickness. It is not clear how Methscopolamine prevents nausea and vomiting du...
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Mechanism of Action: Methscopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center). It does so by acting as a muscarinic antagonist.
Absorption: Poorly and unreliably absorbed, total absorption is 10-25%.
Biotransformation: Little is known about the fate and excretion of methscopolamine.
Toxicity: Symptoms of a methscopolamine overdose include headache, nausea, vomiting, dry mouth, difficulty swallowing, blurred vision, dilated pupils, hot, dry skin, dizziness; drowsiness, confusion, anxiety, seizures, weak pulse, and an irregular heartbeat. In addition, a curare-like action may occur, i.e., neuromuscular blockade leading to muscular weakness and possible paralysis.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
TacrineThe therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Methylscopolamine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
DonepezilPossible antagonism of action
TrospiumTrospium and Methylscopolamine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
TrimethobenzamideTrimethobenzamide and Methylscopolamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
TriprolidineTriprolidine and Methylscopolamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
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Targets