QuickView for nectin-1 (gene)

Gene Symbol:

NECTIN1 Homo sapiens

Full name:

nectin cell adhesion molecule 1

Synonyms:

CD111, CLPED1, ED4, HIgR, HV1S, HVEC, OFC7, PRR, PRR1, PVRL1, PVRR, PVRR1, SK-12, nectin-1, nectin-1, ectodermal dysplasia 4 (Margarita Island type), herpes simplex virus type 1 sensitivity, herpes virus entry mediator C, herpesvirus Ig-like receptor, nectin 1, poliovirus receptor-like 1, poliovirus receptor-related 1 (herpesvirus entry mediator C), poliovirus receptor-related protein 1

Genomic Location:

Chr 11: 119014018-119104645

Description:

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domai...

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This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  HNF1_01 ,  FOXJ2_02 ,  FOX_Q2 ,  HFH3_01 ,  NFAT_Q6 ,  E2F1_Q4_01 ,  SMAD3_Q6 ,  E4BP4_01 ,  TTCNRGNNNNTTC_HSF_Q6 ,  YNTTTNNNANGCARM_UNKNOWN ,  VDR_Q6 ,  LYF1_01 ,  E2F_Q6_01 ,  SRY_01 ,  E2F_01 ,  HNF1_C ,  SREBP1_Q6 ,  TTAYRTAA_E4BP4_01 ,  E2F1_Q4 ,  MYAATNNNNNNNGGC_UNKNOWN ,  E2F_Q6 ,  TEF1_Q6 ,  CEBP_01 ,  CAGGTG_E12_Q6 ,  HNF3_Q6 ,  SP3_Q3 ,  E2F_Q4 ,  HNF3B_01 ,  FOXJ2_01 ,  GGGCGGR_SP1_Q6 ,  E2F1_Q3_01 ,  TGCCAAR_NF1_Q6 ,  E2F_03 ,  E2F_Q4_01 ,  RNGTGGGC_UNKNOWN ,  E2F1DP1RB_01 ,  ARGGGTTAA_UNKNOWN ,  GATA1_05 ,  SREBP_Q3 ,  GTGGGTGK_UNKNOWN ,  RORA2_01 ,  PAX3_B ,  AACTTT_UNKNOWN ,  PAX4_03 ,  E2F_Q3 ,  E2F_Q3_01 ,  GGGTGGRR_PAX4_03 ,  E2F1_Q6

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Cytogenetic Map:

11q23.3

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