QuickView for neutrophil infiltration (biogroup)

Description:: Junctional adhesion molecule-like (JAML) contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail. JAML mRNA is expressed in hematopoietic tissues and is localised at the cell plasma membrane in the areas of cell-cell contacts. It is a receptor that controls the migration and activation of the epithelial gamma-delta T cells through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. During acute inflammation, neutrophils infiltrate the intestinal mucosa. JAML can be cleaved from the neutrophil surface by zinc metalloproteases during theneutrophil transepithelial migration (TEM). These neutrophil-derived soluble JAML can bind to the epithelial tight junction protein coxsackie-adenovirus receptor (CAR) and decrease epithelial proliferation, inhibiting wound repair and promoting the recruitment of leukocytes.
Taxonomy/Path:: InterPro : Myelin P0 protein-related / Junctional adhesion molecule-like

1 feature

Symbol	EntrezGene ID
JAML	120425