Name: | NFATC Transcription Factors |
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Description: | A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2. |
Synonyms: |
NF AT Proteins; Nuclear Factor of Activated T Cells 5 Protein; Nuclear Factor of Activated T-Cells 5 Protein; NFAT5 Protein; Tonicity-Responsive Enhancer-Binding Protein; Nuclear Factors of Activated T-Cells; NFATz Protein; NFATC Proteins; NFAT Transcription Factor 5; OREBP Protein.
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