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QuickView for niclosamide (compound)
PubChem
| Name: | Niclosamide |
|---|---|
| PubChem Compound ID: | 10925418 |
| Description: | An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48) |
| Molecular formula: | C13H8Cl2N2O4 |
| Molecular weight: | 326.12 g/mol |
DrugBank
Identification
| Name: | Niclosamide |
|---|---|
| Name (isomeric): | DB06803 |
| Drug Type: | small molecule |
| Description: | An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48) |
| Brand: | Niclocide |
| Category: | Antiparasitic Agents, Anthelmintics |
| CAS number: | 50-65-7 |
Pharmacology
| Indication: | For the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis. |
|---|---|
| Pharmacology: | Niclosamide is an antihelminth used against tapeworm infections. It may act by the uncoupling of the electron transport chain to ATP synthase. The disturbance of this crucial metabolic pathway prevents creation of adenosine tri-phosphate (ATP), an essential molecule that supplies energy for metabolism. |
| Mechanism of Action: | Niclosamide works by killing tapeworms on contact. Adult worms (but not ova) are rapidly killed, presumably due to uncoupling of oxidative phosphorylation or stimulation of ATPase activity. The killed worms are then passed in the stool or sometimes destroyed in the intestine. Niclosamide may work as a molluscicide by binding to and damaging DNA. |
| Absorption: | Niclosamide appears to be minimally absorbed from the gastrointestinal tract—neither the drug nor its metabolites have been recovered from the blood or urine. |
| Toxicity: | Infrequent, mild, and transitory adverse events include nausea, vomiting, diarrhea, and abdominal discomfort. |
| Affected organisms: | Helminthic Microorganisms |
Targets
