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QuickView for niflumic acid (compound)
PubChem
| Name: | Niflumic Acid |
|---|---|
| PubChem Compound ID: | 4488 |
| Description: | An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. |
| Molecular formula: | C13H9F3N2O2 |
| Molecular weight: | 282.218 g/mol |
| Synonyms: |
Niflumic Acid; KBioGR_000505; SC 1332; 2-(3-Trifluoromethyl-phenylamino)-nicotinic acid; NINDS_000277; BAS 00821161; NFA; Spectrum4_000043; Prestwick_890; Actol.
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DrugBank
Identification
| Name: | Niflumic Acid |
|---|---|
| Name (isomeric): | DB04552 |
| Drug Type: | small molecule |
| Description: | An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. |
| Synonyms: |
Nifluminic acid; 2-(3-(Trifluoromethyl)anilino)nicotinic acid; 2-(3-Trifluoromethyl-phenylamino)-nicotinic acid; Acide niflumique [inn-french]; Niflumate; NFA; Lopac-N-0630; Acido niflumico [inn-spanish]; 2-[(3-Trifluoromethyl)Phenyl]Amino-3-Pyridine-Carboxylic Acid; NFL.
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| Brand: | Landruma, Flogovital, Niflam, Nifluril, Forenol, Actol |
| Category: | Cyclooxygenase Inhibitors |
| CAS number: | 4394-00-7 |
Pharmacology
| Indication: | Used in the treatment of rheumatoid arthritis. |
|---|---|
| Pharmacology: | Niflumic acid, a nonsteroidal anti-inflammatory fenamate, is a Ca2+-activated Cl- channel blocker. |
| Mechanism of Action: | Niflumic acid is able to inhibit both phospholipase A2 as well as COX-2, thereby acting as an antiinflamatory and pain reduction agent. |
| Absorption: | Well absorbed following oral administration. |
| Protein binding: | 90% bound to plasma proteins. |
| Biotransformation: | Hepatic. |
| Half Life: | 2.5 hours |
| Toxicity: | Oral, mouse: LD50 = 350 mg/kg; Oral, rat: LD50 = 250 mg/kg |
| Affected organisms: | Humans and other mammals |
Targets
Transporters
