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QuickView for nitroprusside (compound)
PubChem
| Name: | Nitroprusside |
|---|---|
| PubChem Compound ID: | 11953891 |
| Description: | A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins. |
| Molecular formula: | C5FeN6O |
| Molecular weight: | 215.938 g/mol |
| Synonyms: |
Sodium nitroprusside; 15078-28-1; 14402-89-2; 13755-38-9; NITROPRUSSIDE; C07269; Ferrate(2-), pentakis(cyano-C)nitrosyl-, (OC-6-22)-; Nitroferricyanide
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DrugBank
Identification
| Name: | Nitroprusside |
|---|---|
| Name (isomeric): | DB00325 |
| Drug Type: | small molecule |
| Description: | A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins. |
| Synonyms: |
Sodium Nitroprusside; Sodium nitroprusside dihydrate; Sodium nitroferricyanide dihydrate; Disodium nitroprusside dihydrate
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| Brand: | Nitropress, Nipride |
| Brand name mixture: | Cora-Bosan B43(Potassium Carbonate + Sodium Nitroprusside + Squill) |
| Category: | Indicators and Reagents, Vasodilator Agents, Antihypertensive Agents, Nitric Oxide Donors |
| CAS number: | 15078-28-1 |
Pharmacology
| Indication: | For immediate reduction of blood pressure of patients in hypertensive crises, reduce bleeding during surgery, and for the treatment of acute congestive heart failure |
|---|---|
| Pharmacology: | Nitroprusside a powerful vasodilator relaxes the vascular smooth muscle and produce consequent dilatation of peripheral arteries and veins. Other smooth muscle (e.g., uterus, duodenum) is not affected. Sodium nitroprusside is more active on veins than on arteries. |
| Mechanism of Action: |
One molecule of sodium nitroprusside is metabolized by combination with hemoglobin to produce one molecule of cyanmethemoglobin and four CN- ions; methemoglobin, obtained from hemoglobin, can sequester cyanide as cyanmethemoglobin; thiosulfate reacts with cyanide to produce thiocyanate; thiocyanate is eliminated in the urine; cyanide not otherwise ...
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| Biotransformation: | Metabolized by reaction with hemoglobin to produce cyanmethemoglobin and cynide ions |
| Route of elimination: | One molecule of sodium nitroprusside is metabolized by combination with hemoglobin to produce one molecule of cyanmethemoglobin and four CN¯ ions, thiosulfate reacts with cyanide to produce thiocyanate, thiocyanate is eliminated in the urine. |
| Half Life: | Approximately 2 minutes |
| Toxicity: | Overdosage of nitroprusside can be manifested as excessive hypotension or cyanide toxicity or as thiocyanate toxicity. The acute intravenous mean lethal doses (LD50) of nitroprusside in rabbits, dogs, mice, and rats are 2.8, 5.0, 8.4, and 11.2 mg/kg, respectively. |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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Targets
Enzymes
