QuickView for nociceptin receptor (gene)
- Gene Symbol:
- OPRL1
Homo sapiens - Full name:
- opioid related nociceptin receptor 1
- Synonyms:
- KOR-3, NOCIR, NOP, NOPr, OOR, ORL1, nociceptin receptor, kappa-type 3 opioid receptor, kappa3-related opioid receptor, nociceptin/orphanin FQ receptor, opiate receptor-like 1, orphanin FQ receptor
- Genomic Location:
- Chr 20: 62181932-62202440
- Description:
-
The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavio...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
20q13.33
GO Molecular Function
peptide binding | transmembrane signaling receptor activity | neuropeptide binding | G-protein coupled receptor activity | amide binding | signaling receptor activity | opioid receptor activity | protein binding | nociceptin receptor activity | peptide receptor activity | G-protein coupled peptide receptor activity | protein C-terminus binding
GO Biological Process
negative regulation of G-protein coupled receptor protein signaling pathway | regulation of localization | negative regulation of voltage-gated calcium channel activity | response to hormone | negative regulation of cellular process | cellular chemical homeostasis | positive regulation of sensory perception of pain | positive regulation of neurological system process | cellular process | neuropeptide signaling pathway | cellular homeostasis | negative regulation of signaling | response to estradiol | regulation of digestive system process | multicellular organismal reproductive process | regulation of behavior | regulation of neurological system process | positive regulation of gastric acid secretion | regulation of cellular process | regulation of cytosolic calcium ion concentration | regulation of urine volume | calcium ion homeostasis | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | G-protein coupled receptor activity | response to stimulus | ovulation cycle | negative regulation of transporter activity | reproduction | rhythmic process | negative regulation of transport | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of calcium ion transmembrane transport | negative regulation of transmembrane transport | metal ion homeostasis | negative regulation of blood pressure | reproductive process | regulation of signal transduction | positive regulation of urine volume | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | regulation of sensory perception of pain | opioid receptor signaling pathway | positive regulation of secretion | response to lipid | nervous system process | regulation of blood pressure | cellular ion homeostasis | positive regulation of cytosolic calcium ion concentration | regulation of gastric acid secretion | positive regulation of digestive system process | negative regulation of ion transmembrane transport | negative regulation of calcium ion transmembrane transporter activity | sensory perception of pain | eating behavior | negative regulation of ion transport | regulation of calcium ion transmembrane transport | regulation of voltage-gated calcium channel activity | cation homeostasis | cellular cation homeostasis | cell communication | negative regulation of cation channel activity | negative regulation of calcium ion transport | regulation of cAMP-mediated signaling | cellular calcium ion homeostasis | homeostatic process | positive regulation of transport | opioid receptor activity | multicellular organism reproduction | response to organic substance | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of body fluid levels | chemical homeostasis | nociceptin receptor activity | regulation of secretion | behavior | negative regulation of ion transmembrane transporter activity | ion homeostasis | regulation of ion transmembrane transport | phospholipase C-activating G-protein coupled receptor signaling pathway | renal system process | sensory perception | estrous cycle | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | feeding behavior | G-protein coupled peptide receptor activity | response to organic cyclic compound | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | regulation of circadian rhythm | regulation of ion transport | regulation of G-protein coupled receptor protein signaling pathway | negative regulation of cAMP-mediated signaling | regulation of calcium ion transport | regulation of transport | regulation of cation channel activity | cellular metal ion homeostasis | regulation of calcium ion transmembrane transporter activity | regulation of locomotor rhythm | divalent inorganic cation homeostasis | signal transduction | regulation of signaling | multicellular organismal process
GO Cellular Component
integral component of membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | plasma membrane | vesicle | integral component of plasma membrane | membrane-bounded organelle | organelle | cell periphery | intracellular vesicle | intracellular | membrane | intrinsic component of plasma membrane
