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QuickView for noradrenaline (compound)


PubChem
Name: Norepinephrine
PubChem Compound ID: 10781614
Description: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Molecular formula: C13H17NO8
Molecular weight: 315.276 g/mol
DrugBank
Identification
Name: Norepinephrine
Name (isomeric): DB00368
Drug Type: small molecule
Description: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Synonyms:
L-noradrenaline; L-Norepinephrine; Noradrenaline; Arterenol
Brand: Levophed
Category: Adrenergic alpha-Agonists, Sympathomimetics, Vasoconstrictor Agents
CAS number: 51-41-2
Pharmacology
Indication: Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
Pharmacology: Noradrenaline acts on both alpha-1 and alpha-2 adrenergic receptors to cause vasoconstriction. Its effect in-vitro is often limited to the increasing of blood pressure through antagonising alpha-1 and alpha-2 receptors and causing a resultant increase in systemic vascular resistance.
Mechanism of Action: Norepinephrine functions as a peripheral vasoconstrictor by acting on alpha-adrenergic receptors. It is also an inotropic stimulator of the heart and dilator of coronary arteries as a result of it's activity at the beta-adrenergic receptors.
Toxicity: In high dose and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
PhenelzineIncreased arterial pressure
GuanethidineNorepinephrine may decrease the effect of guanethidine.
IsocarboxazidIncreased arterial pressure
NortriptylineThe tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of norepinephrine.
ReserpineIncreased arterial pressure
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