Bookmark
Forward
QuickView for novobiocin (compound)
PubChem
| Name: | Novobiocin |
|---|---|
| PubChem Compound ID: | 20297 |
| Description: | An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) |
| Molecular formula: | C31H35CaN2O11+ |
| Molecular weight: | 651.694 g/mol |
| Synonyms: |
Albamycin Syrup; Benzamide, N-(7-((3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-beta-L-lyxo-hexopyranosyl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl)-4-hydroxy-3-(3-methyl-2-butenyl)-, calcium salt (2:1); 4309-70-0; 303-81-1; Novobiocin, calcium salt; EINECS 224-321-2; NOVOBIOCIN CALCIUM
|
DrugBank
Identification
| Name: | Novobiocin |
|---|---|
| Name (isomeric): | DB01051 |
| Drug Type: | small molecule |
| Description: | An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) |
| Synonyms: |
Novobiocina [INN-Spanish]; Crystallinic Acid; Novobiocinum [INN-Latin]; Antibiotic Pa-93; NOV; Novobiocine [INN-French]
|
| Brand: | Stilbiocina, Spheromycin, Sirbiocina, Cathocin, Albamix, Albamycin, Novo-R, Cardelmycin, Cathomycin, Streptonivicin, Robiocina, Inamycin |
| Brand name mixture: | Albacillin Suspension(Novobiocin (Novobiocin Sodium) + Penicillin G Procaine), Novodry Plus Suspension(Novobiocin (Novobiocin Sodium) + Penicillin G Procaine), Special Formula 17900-Forte Suspension(Dihydrostreptomycin (Dihydrostreptomycin Sulfate) + Hydrocortisone Acetate + Hydrocortisone Sodium Succinate + Novobiocin (Novobiocin Sodium) + Peni... show more » |
| Category: | Anti-Bacterial Agents, Enzyme Inhibitors, Nucleic Acid Synthesis Inhibitors |
| CAS number: | 303-81-1 |
Pharmacology
| Indication: | For the treatment of infections due to staphylococci and other susceptible organisms |
|---|---|
| Pharmacology: | Novobiocin is an aminocoumarin antibiotic that was produced by the actinomycete Streptomyces niveus. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. Other antibiotics in the aminocoumarin class include coumermycin A1 and clorobiocin. |
| Mechanism of Action: | Novobiocin is an aminocoumarin. Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by inhibiting the GyrB subunit of the enzyme involved in energy tranduction. Novobiocin as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB. |
| Absorption: | Oral bioavailability is negligible. |
| Protein binding: | 95% |
| Half Life: | 6 hours |
| Affected organisms: | Enteric bacteria and other eubacteria |
Targets
Transporters
