Name: | olmesartan |
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PubChem Substance ID: | 707351 |
Synonyms: |
Benicar; Votum; DE-092; Olmetec; Olmesartan; Olmesartan medoximil; Olmesartan medoxomil
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Name: | olmesartan |
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Name (isomeric): | DB00275 |
Drug Type: | small molecule |
Synonyms: |
DE-092; Olmesartan medoximil; Olmesartan medoxomil
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Brand: | Olmetec, Benicar, Votum, Benicar HCT |
Category: | Angiotensin II Type 1 Receptor Blockers, Antihypertensive Agents |
CAS number: | 144689-63-4 |
Indication: | For the treatment of hypertension. |
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Pharmacology: |
Olmesartan, a specific angiotensin II type 1 antagonist, is used alone or with other antihypertensive agents to treat hypertension. Unlike the angiotensin receptor antagonist losartan, olmesartan does not have an active metabolite or possess uricosuric effects. Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of ang...
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Mechanism of Action: |
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation and renal reabsorption of sodium....
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Absorption: | Bioavailability is about 26%. Food does not affect the bioavailability of olmesartan. |
Protein binding: | Highly bound to plasma proteins (99%) and does not penetrate red blood cells. |
Biotransformation: | Olmesartan is rapidly and completely bioactivated by ester hydrolysis to olmesartan during absorption from the gastrointestinal tract. There is virtually no further metabolism of olmesartan. |
Half Life: | Approximately 13 hours |
Clearance: | Total plasma cl=1.3 L/h Renal cl=0.6 L/h |
Toxicity: | Symptoms of overdose include dehydration (dry mouth, excessive thirst, muscle pain or cramps, nausea and vomiting, weakness), dizziness, low blood pressure, and slow or irregular heartbeat. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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Drug interaction: |
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