Name: | Ouabain |
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PubChem Compound ID: | 12420 |
Description: | A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE. |
Molecular formula: | C29H44O12 |
Molecular weight: | 584.652 g/mol |
Synonyms: |
630-60-4; Uabanin; Quabain; Ouabain; Oubain; Ouabaine; BRN 0101712; 36-06-6; Kombetin; SDCCGMLS-0066608.P001.
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Name: | Ouabain |
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Name (isomeric): | DB01092 |
Drug Type: | small molecule |
Description: | A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE. |
Synonyms: |
Ouabain, Octahydrate; Strophanthin-G; Strophanthin G; Ouabaine; Ouabagenin L-Rhamnoside; Ouabain Octahydrate; G-Strophanthin
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Brand: | Gratibain, Acocantherin, Strodival, Uabaina, Rectobaina, Gratus Strophanthin, Purostrophan, Solufantina, Strophosan, Strophoperm, G-Strophicor, Astrobain, Strophalen, Kombetin, Uabanin |
Category: | Cardiotonic Agents, Enzyme Inhibitors |
CAS number: | 630-60-4 |
Indication: | For the treatment of atrial fibrillation and flutter and heart failure |
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Pharmacology: | Ouabain, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. |
Mechanism of Action: |
Ouabain inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Ouabain also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization...
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Protein binding: | 60% |
Affected organisms: | Humans and other mammals |