QuickView for p15INK4b (gene)

Gene Symbol:

CDKN2B Homo sapiens

Full name:

cyclin dependent kinase inhibitor 2B

Synonyms:

CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, cyclin-dependent kinase 4 inhibitor B, CDK inhibitory protein, CDK4B inhibitor, MTS-2, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), cyclin-dependent kinases 4 and 6 binding protein, multiple tumor suppressor 2, p14-INK4b, p14_CDK inhibitor, p14_INK4B, p15 CDK inhibitor, p15-INK4b, p15_INK4B

Genomic Location:

Chr 9: 21992902-21999312

Description:

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that...

View Full Description

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGIF_01 ,  IPF1_Q4 ,  VDR_Q6 ,  NRSF_01 ,  GGGYGTGNY_UNKNOWN ,  MEIS1_01 ,  YCATTAA_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  RCGCANGCGY_NRF1_Q6 ,  TCF11_01

Cytogenetic Map:

9p21.3

search → result