QuickView for p90 ribosomal S6 kinase (gene)

Gene Symbol:

RPS6KA3 Homo sapiens

Full name:

ribosomal protein S6 kinase A3

Synonyms:

CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2, ribosomal protein S6 kinase alpha-3, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, RSK-2, S6K-alpha-3, insulin-stimulated protein kinase 1, p90-RSK 3, ribosomal S6 kinase 2, ribosomal protein S6 kinase, 90kDa, polypeptide 3

Genomic Location:

Chr X: 20077950-20194671

Description:

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth ...

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This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CTTGTAT_MIR381 ,  GABP_B ,  ATAAGCT_MIR21 ,  GTGCCAT_MIR183 ,  TGANTCA_AP1_C ,  GATA1_01 ,  CCCAGAG_MIR326 ,  TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  AAAGGGA_MIR204_MIR211 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  E4BP4_01 ,  NGFIC_01 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  WGTTNNNNNAAA_UNKNOWN ,  CTCNANGTGNY_UNKNOWN ,  MAF_Q6 ,  GCCATNTTG_YY1_Q6 ,  MYCMAX_B ,  CREB_Q4 ,  E2F1_Q4 ,  ATAGGAA_MIR202 ,  STAT_Q6 ,  AGCATTA_MIR155 ,  TAATGTG_MIR323 ,  TTGGAGA_MIR5155P_MIR519E ,  GGGYGTGNY_UNKNOWN ,  CATTTCA_MIR203 ,  CAGGTA_AREB6_01 ,  GGATTA_PITX2_Q2 ,  CAGGTG_E12_Q6 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  TTCYRGAA_UNKNOWN ,  RRAGTTGT_UNKNOWN ,  ATTCTTT_MIR186 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GGGCGGR_SP1_Q6 ,  CREBP1_01 ,  GGCNRNWCTTYS_UNKNOWN ,  E4F1_Q6 ,  MGGAAGTG_GABP_B ,  AP2_Q3 ,  RNGTGGGC_UNKNOWN ,  HLF_01 ,  GGCACTT_MIR519E ,  MTF1_Q4 ,  SCGGAAGY_ELK1_02 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  CREB_Q2 ,  SMAD4_Q6 ,  CTGCAGY_UNKNOWN ,  CCCNNNNNNAAGWT_UNKNOWN ,  EGR1_01 ,  CCATCCA_MIR432 ,  AGGCACT_MIR5153P ,  AACTTT_UNKNOWN ,  CRX_Q4 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ATGAAGG_MIR205 ,  CREB_Q2_01 ,  ACATATC_MIR190 ,  GGGTGGRR_PAX4_03 ,  AAGCACA_MIR218 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-190 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-216 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-410

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Cytogenetic Map:

Xp22.12

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