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QuickView for papaverine (compound)

Summary
General Info

PubChem

PubChem Compound 4680

PubChem Compound 4680

Name:	Papaverine
PubChem Compound ID:	4680
Description:	An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Molecular formula:	C₂₀H₂₁NO₄
Molecular weight:	339.385 g/mol
Synonyms:	ZINC00056555; Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-; KBio2_005607; SPBio_001015; Paverolan; Qua bid; Ceraspan; Pavabid; Papaverin; Papaverine, hydrochloride. show more » ZINC00056555; Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-; KBio2_005607; SPBio_001015; Paverolan; Qua bid; Ceraspan; Pavabid; Papaverin; Papaverine, hydrochloride; BRN 0312930; SDCCGMLS-0003037.P003; 6,7,3',4'-Tetramethoxy-1-benzylisoquinoline hydrochloride; KBio2_003039; Papavarine chlorhydrate; Isoquinoline, 6,7-dimethoxy-1-veratryl-, hydrochloride; Papanerin-hcl; C06533; 61-25-6; 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride; Vasospan; Lopac-P-3510; Isoquinoline, 1-[ (3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-; Prestwick1_000583; Durapav; Cardoverina; EINECS 200-397-2; Papanerin; NSC 136630; Drapavel; Vaso-Pav; Papacon; Isoquinoline, 6,7-dimethoxy-1-veratryl-(8Cl); Pavnell; Pameion; Pap-Kaps-150; Papaverine; Papaversan; 1-[(3,4-Dimethoxyphenyl)methyl]6,7-dimethoxyisoquinoline; PAP H; NINDS_000321; TNP00305; Alapav; RS 47; Chlorhydrate de papaverine; Papaverine monohydrochloride; KBio3_001653; 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline; Spectrum4_000467; Pavacen; Paveron; AIDS000185; InChI=1/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H; 1-((3,4-Dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline; Cardiospan; NCI-C56359; NSC136630; Papaverine hydrochloride; Pavatest; DivK1c_000321; 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-isoquinoline; KBio2_000471; Papaverinium chloride; Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-; KBioSS_000471; 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline; KBioGR_000914; Papaverine chlorohydrate; Pavacot; component of Copavin; Delapav; Cerebid; Myobid; HSDB 3147; Papanerine; Dispamil; Papaverina [Italian]; Prestwick0_000583; Robaxapap; Spectrum2_000978; Forpavin; NCGC00015810-02; Spectrum3_000537; NCGC00015810-01; Papalease; NSC35443; 4-[(6,7-Dimethoxyisoquinolyl)methyl]-1,2-dimethoxybenzene; NCGC00015810-03; SPBio_002645; Isoquinoline, 6,7-dimethoxy-1-veratryl- (8CI); Dynovas; Ro-Papav; AIDS-000185; Vasal; Isoquinoline, 1-[ (3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, hydrochloride; 58-74-2; Isoquinoline, 6,7-dimethoxy-1-veratryl-; NCI60_003183; CAS-61-25-6; 5-21-06-00182 (Beilstein Handbook Reference); BAS 00674058; Pamelon; 6,7-Dimethoxy-1-veratrylisoquinoline; Cerespan; Pavacap; KBio1_000321; Spectrum_000071; Dilaves; S-M-R show less «

DrugBank

Identification

Name:	Papaverine
Name (isomeric):	DB01113
Drug Type:	small molecule
Description:	An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Synonyms:	Papaverin; Papaverine Chlorohydrate; Papaverine Hydrochloride; Papavarine Chlorhydrate; Papaverine Hcl; Papaverinium Chloride; Papaverine Monohydrochloride; Chlorhydrate de Papaverine
Brand:	Pavacap, Robaxapap, Dilaves, Papanerin, Pavatym, Alapav, Pavnell, Paptial T.R., Qua Bid, Panergon, Drapavel, Therapav, Vaso-Pav, Cepaverin, Pameion, Paverolan, Cerespan, Spasmo-Nit, Pamelon, Cardiospan, Pavagen, Papanerin-Hcl, Genabid, Papital T.R., Pavabid Hp, Pavabid, Pavacen, Ro-Papav, Delapav, Papanerine, Pavadel, Cerebid, Dynovas, Pap H, Pavarine, Paveron, Pavacels, Dispamil, Myobid, Optenyl, Pavatine, Papalease, Cardoverina, Durapav, Pavakey, Pavased, Forpavin, Pavatest, Vasal, Papacon, Pavacot, Artegodan, Papaversan
Category:	Vasodilator Agents, Phosphodiesterase Inhibitors
CAS number:	61-25-6

Pharmacology

Indication:	For the treatment of impotence and vasospasms.
Pharmacology:	Papaverine is a nonxanthine phosphodiesterase inhibitor for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. The main actions of Papaverine are exerted on cardiac and smooth muscle. Like qathidine, Papaverine acts directly on the heart muscle to depress conduction and ... show more » Papaverine is a nonxanthine phosphodiesterase inhibitor for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. The main actions of Papaverine are exerted on cardiac and smooth muscle. Like qathidine, Papaverine acts directly on the heart muscle to depress conduction and prolong the refractory period. Papaverine relaxes various smooth muscles. This relaxation may be prominent if spasm exists. The muscle cell is not paralyzed by Papaverine and still responds to drugs and other stimuli causing contraction. The antispasmodic effect is a direct one, and unrelated to muscle innervation. Papaverine is practically devoid of effects on the central nervous system. Papaverine relaxes the smooth musculature of the larger blood vessels, especially coronary, systemic peripheral, and pulmonary arteries. show less «
Mechanism of Action:	Perhaps by its direct vasodilating action on cerebral blood vessels, Papaverine increases cerebral blood flow and decreases cerebral vascular resistance in normal subjects; oxygen consumption is unaltered. These effects may explain the benefit reported from the drug in cerebral vascular encephalopathy.
Protein binding:	~90%
Half Life:	0.5-2 hours
Affected organisms:	Humans and other mammals

Interactions

Drug interaction:

Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.

Targets

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A