QuickView for phd3 (gene)
- Gene Symbol:
- EGLN3
Homo sapiens - Full name:
- egl-9 family hypoxia inducible factor 3
- Synonyms:
- HIFP4H3, HIFPH3, PHD3, egl nine homolog 3, HIF-PH3, HIF-prolyl hydroxylase 3, HPH-1, HPH-3, egl nine-like protein 3 isoform, hypoxia-inducible factor prolyl hydroxylase 3, prolyl hydroxylase domain-containing protein 3
- Genomic Location:
- Chr 14: 33463172-33490035
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
14q13.1
GO Molecular Function
cofactor binding | cation binding | L-ascorbic acid binding | carboxylic acid binding | vitamin binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | iron ion binding | coenzyme binding | peptidyl-proline dioxygenase activity | monosaccharide binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | anion binding | peptidyl-proline 4-dioxygenase activity | ion binding | carbohydrate binding | protein binding | dioxygenase activity | transition metal ion binding | organic acid binding | metal ion binding | oxidoreductase activity | small molecule binding
GO Biological Process
cellular response to decreased oxygen levels | regulation of cysteine-type endopeptidase activity | positive regulation of apoptotic process | regulation of programmed cell death | peptidyl-amino acid modification | regulation of neuron death | cellular process | peptidyl-proline modification | response to hypoxia | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | cellular amino acid metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | response to stimulus | positive regulation of protein metabolic process | positive regulation of peptidase activity | cellular response to hypoxia | response to stress | regulation of cell proliferation | positive regulation of cysteine-type endopeptidase activity | programmed cell death | positive regulation of proteolysis | peptidyl-proline hydroxylation | peptidyl-proline dioxygenase activity | protein modification process | macromolecule modification | regulation of nucleic acid-templated transcription | apoptotic process | response to oxygen levels | nitrogen compound metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 4-hydroxyproline metabolic process | regulation of peptidase activity | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of gene expression | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | cellular response to stress | positive regulation of cellular metabolic process | peptidyl-proline 4-dioxygenase activity | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | regulation of transcription by RNA polymerase II | positive regulation of hydrolase activity | regulation of cellular protein metabolic process | positive regulation of endopeptidase activity | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of cellular metabolic process | regulation of neuron apoptotic process | regulation of protein metabolic process | regulation of RNA metabolic process | protein hydroxylation | carboxylic acid metabolic process | positive regulation of molecular function | protein metabolic process | metabolic process | regulation of DNA-templated transcription in response to stress | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of RNA biosynthetic process | oxidation-reduction process | positive regulation of cell death | organic substance metabolic process | cell death | positive regulation of programmed cell death | dioxygenase activity | regulation of transcription, DNA-templated | organic acid metabolic process | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | regulation of endopeptidase activity | regulation of transcription from RNA polymerase II promoter in response to hypoxia | cellular protein modification process | cellular modified amino acid metabolic process | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | oxidoreductase activity | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
