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QuickView for phenylephrine (compound)


PubChem
Name: Phenylephrine
PubChem Compound ID: 11819418
Description: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
Molecular formula: C9H13NO2
Molecular weight: 168.218 g/mol
DrugBank
Identification
Name: Phenylephrine
Name (isomeric): DB00388
Drug Type: small molecule
Description: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
Synonyms:
Metasynephrine; Phenylephrinum [INN-Latin]; M-Oxedrine; M-Methylaminoethanolphenol; Metaoxedrin; L-Phenylephedrine; L-Phenylephrine; Metaoxedrine; Fenilefrina [INN-Spanish]; Metaoxedrinum
Brand: Ocugestrin, Alconefrin Nasal Spray 25, AK-Nefrin, Mezaton, Neo-Synephrine Nasal Spray, Phenoptic, Adrianol, Neophryn, Metsatonum, Relief Eye Drops for Red Eyes, Minims Phenylephrine, Mesaton, Nostril Spray Pump, Isophrin, Isophrim, Alconefrin Nasal Drops 25, Dimetane, Neo-Synephrine, Neofrin, Ocu-Phrin Sterile Eye Drops, Mesatonum, I-Phrine, Dionephrine, Dilatair, Isopto Frin, M-Synephrine, Neo-Synephrine Nasal Jelly, Mydfrin, Spersaphrine, Metasympatol, Duration, Nostril Spray Pump Mild, Nostril, Visadron, Neo-Synephrine Nasal Drops, Doktors, Prefrin, Biomydrin, Mesatone, AK-Dilate, Alcon Efrin, M-Sympatol, Alconefrin Nasal Drops 50, Prefrin Liquifilm, Vicks Sinex, M-Sympathol, Rhinall, Pyracort D, Neosynephrine, Alconefrin Nasal Drops 12
Brand name mixture:
Biohisdine DM Decongestant(Dextromethorphan Hydrobromide + Diphenylpyraline Hydrochloride + Phenylephrine Hydrochloride), Citron Chaud DM Cumberland Pws(Dextromethorphan Hydrobromide + Pheniramine Maleate + Phenylephrine Hydrochloride + Vitamin C), Lemon Relief for Adults(Acetaminophen + Pheniramine Maleate + Phenylephrine Hydrochloride), Vasosu...
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Category: Mydriatics, Adrenergic alpha-Agonists, Cardiotonic Agents, Sympathomimetics, Vasoconstrictor Agents, Nasal Decongestants
CAS number: 59-42-7
Pharmacology
Indication: Phenylephrine is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs.
Pharmacology:
Phenylephrine is a powerful vasoconstrictor. It is used as a nasal decongestant and cardiotonic agent. Phenylephrine is a postsynaptic α1-receptor agonist with little effect on β-receptors of the heart. Parenteral administration of phenylephrine causes a rise in systolic and diastolic pressures, a slight decrease in cardiac ou...
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Mechanism of Action:
In general, α1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. α1-receptors are 7-transmembrane domain receptors coupled to G proteins, Gq/11. Three α1-receptor subtypes, which share approximately 75% homology in their transmembrane domains, have ...
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Absorption: Completely absorbed after oral administration. It has a reduced bioavailability (compared to pseudoephedrine) following oral administration due to significant first-pass metabolism in the intestinal wall. Compared to IV administration, bioavailability is approximately 38%. Peak serum concentrations are achieved approximately 0.75-2 hours following oral administration. Phenylephrine should be administered parenterally to achieve cardiovascular effects. Occasionally, systemic effects are observed following oral inhalation.
Protein binding: 95% binding-plasma proteins
Biotransformation: Undergoes extensive first-pass metabolism in the intestinal wall and extensive metabolism in the liver. Sulfate conjugation, primarily in the intestinal wall, and oxidative metabolism by monoamine oxidase (MAO) represent the principle routes of metabolism. Glucuronidation occurs to a lesser extent. Phenylephrine and its metabolites are mainly excreted in urine/ .
Half Life: 2.1 to 3.4 hours
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take without regard to meals.
Drug interaction:
PhenelzineIncreased arterial pressure
AlseroxylonIncreased arterial pressure
ErgonovinePossible marked increase of arterial pressure
ReserpineIncreased arterial pressure
ClomipramineThe tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of phenylephrine.
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Targets


Enzymes