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QuickView for phospholamban (gene)


Gene Symbol:
PLN Homo sapiens Homo sapiens
Full name:
phospholamban
Synonyms:
CMD1P, CMH18, PLB, cardiac phospholamban
Genomic Location:
Chr 6: 118976165-118988280
Description:
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation ...
Orthologs:
Mus musculus Rattus norvegicus Bos taurus Gallus gallus Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 6
6q22.31


Transcripts Names
NM_002667
Protein Names
Q5R352
P26678



GO Molecular Function

channel regulator activity | enzyme binding | enzyme inhibitor activity | molecular function regulator | ATPase binding | identical protein binding | protein binding | calcium channel regulator activity | enzyme regulator activity | ATPase regulator activity | ATPase inhibitor activity

GO Biological Process

Notch signaling pathway | protein homooligomerization | regulation of muscle system process | negative regulation of intracellular transport | heart process | regulation of cellular localization | muscle tissue development | intracellular signal transduction | regulation of localization | negative regulation of calcium ion import into sarcoplasmic reticulum | establishment of localization | response to hormone | response to metal ion | cellular chemical homeostasis | relaxation of cardiac muscle | negative regulation of heart rate | cellular process | channel regulator activity | localization | cellular homeostasis | regulation of calcium-mediated signaling | metal ion transport | response to inorganic substance | response to peptide hormone | tissue development | regulation of binding | regulation of cellular process | regulation of cytosolic calcium ion concentration | regulation of relaxation of muscle | cellular component organization | calcium ion homeostasis | response to stimulus | enzyme inhibitor activity | regulation of ATPase activity | adenylate cyclase-activating adrenergic receptor signaling pathway | regulation of cardiac muscle contraction by calcium ion signaling | regulation of blood circulation | regulation of cardiac muscle cell contraction | response to peptide | cardiac muscle tissue development | regulation of heart rate | negative regulation of transporter activity | divalent metal ion transport | regulation of the force of heart contraction by cardiac conduction | negative regulation of transport | blood circulation | G-protein coupled receptor signaling pathway | cellular component assembly | regulation of cardiac muscle cell membrane potential | negative regulation of calcium ion transmembrane transport | negative regulation of transmembrane transport | regulation of intracellular transport | molecular function regulator | metal ion homeostasis | regulation of membrane potential | response to nitrogen compound | regulation of calcium ion transport into cytosol | system development | regulation of signal transduction | multicellular organism development | negative regulation of catalytic activity | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | relaxation of muscle | adenylate cyclase-activating G-protein coupled receptor signaling pathway | protein complex oligomerization | regulation of muscle contraction | regulation of catalytic activity | response to ketone | response to lipid | adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process | cellular ion homeostasis | regulation of cellular component movement | negative regulation of calcium ion binding | regulation of the force of heart contraction | negative regulation of binding | second-messenger-mediated signaling | regulation of release of sequestered calcium ion into cytosol | negative regulation of ion transmembrane transport | negative regulation of calcium ion transmembrane transporter activity | negative regulation of ion transport | negative regulation of calcium-transporting ATPase activity | regulation of calcium ion transmembrane transport | regulation of heart contraction | cation homeostasis | regulation of striated muscle contraction | striated muscle tissue development | regulation of relaxation of cardiac muscle | cellular cation homeostasis | cell communication | response to testosterone | negative regulation of calcium ion transport | cyclic-nucleotide-mediated signaling | regulation of cardiac muscle contraction | heart development | cellular calcium ion homeostasis | homeostatic process | response to zinc ion | calcium-mediated signaling | regulation of ryanodine-sensitive calcium-release channel activity | calcium channel regulator activity | protein-containing complex assembly | response to organic substance | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | negative regulation of ATPase activity | cAMP-mediated signaling | regulation of intracellular signal transduction | response to insulin | anatomical structure development | cell surface receptor signaling pathway | negative regulation of heart contraction | chemical homeostasis | calcium ion transport | G-protein coupled receptor signaling pathway involved in heart process | negative regulation of ion transmembrane transporter activity | regulation of sequestering of calcium ion | animal organ development | ion homeostasis | negative regulation of calcium ion import | regulation of ion transmembrane transport | regulation of calcium ion import | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of molecular function | signaling | response to organic cyclic compound | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | enzyme regulator activity | cation transport | regulation of ion transport | developmental process | regulation of calcium ion transport | regulation of calcium-transporting ATPase activity | regulation of transport | adrenergic receptor signaling pathway | ATPase regulator activity | regulation of cation channel activity | response to organonitrogen compound | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | cellular metal ion homeostasis | negative regulation of hydrolase activity | regulation of actin filament-based process | regulation of calcium ion transmembrane transporter activity | ion transport | circulatory system development | ATPase inhibitor activity | divalent inorganic cation homeostasis | muscle system process | signal transduction | regulation of signaling | cardiac conduction | multicellular organismal process

GO Cellular Component

integral component of membrane | sarcoplasmic reticulum | intracellular membrane-bounded organelle | catalytic complex | organelle membrane | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | cation-transporting ATPase complex | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | calcium ion-transporting ATPase complex | vesicle | perinuclear region of cytoplasm | mitochondrion | membrane-bounded organelle | sarcoplasmic reticulum membrane | organelle | mitochondrial envelope | sarcoplasm | transmembrane transporter complex | ATPase complex | mitochondrial membrane | intracellular | membrane