QuickView for phylloquinone (compound)

Summary
General Info

PubChem

PubChem Compound 10863350

Name:	Vitamin K 1
PubChem Compound ID:	10863350
Description:	A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.
Molecular formula:	C₃₁H₄₆O₂
Molecular weight:	452.696 g/mol

DrugBank

Identification

Name:	Vitamin K 1
Name (isomeric):	DB01022
Drug Type:	small molecule
Description:	A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.
Synonyms:	3-Phytylmenadione; alpha-Phylloquinone; Phytomenadione; 2', 3'-trans-Vitamin K1; Vitamin K1; 2-Methyl-3-phythyl-1,4-naphthochinon; Phyllochinon; Phylloquinone; Phythyl-menadion (GERMAN); Phytylmenadione. show more » 3-Phytylmenadione; alpha-Phylloquinone; Phytomenadione; 2', 3'-trans-Vitamin K1; Vitamin K1; 2-Methyl-3-phythyl-1,4-naphthochinon; Phyllochinon; Phylloquinone; Phythyl-menadion (GERMAN); Phytylmenadione; Vitamin K; Antihemorrhagic vitamin show less «
Brand:	Konakion, K-Ject, Aqua-Mephytin, Kativ N, AquaMEPHYTON, Combinal K1, Monodion, Mono-Kay, Mephyton, Kephton, Kinadion, Synthex P
Category:	Antifibrinolytic Agents, Vitamins, Vitamins (Vitamin K)
CAS number:	84-80-0

Pharmacology

Indication:	For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia
Pharmacology:	Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as d... show more » Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X). show less «
Mechanism of Action:	Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hepatic precursors of coagulation factors II (prothrombin), VII, IX and X. Gamma-carboxylation converts these inactive precursors into active coagulation factors which are secreted by he... show more » Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hepatic precursors of coagulation factors II (prothrombin), VII, IX and X. Gamma-carboxylation converts these inactive precursors into active coagulation factors which are secreted by hepatocytes into the blood. Supplementing with Phytonadione results in a relief of vitamin K deficiency symptoms which include easy bruisability, epistaxis, gastrointestinal bleeding, menorrhagia and hematuria. show less «
Absorption:	Oral phytonadione is adequately absorbed from the gastrointestinal tract only if bile salts are present. After absorption, phytonadione is initially concentrated in the liver, but the concentration declines rapidly. Very little vitamin K accumulates in tissues.
Route of elimination:	Almost no free unmetabolized vitamin K appears in bile or urine.
Toxicity:	The intravenous LD₅₀ of phytonadione in the mouse is 41.5 and 52 mL/kg for the 0.2% and 1% concentrations, respectively.
Affected organisms:	Humans and other mammals

Interactions

Drug interaction:

Warfarin

Phytonadione (vitamin K) may antagonize the anticoagulant effects of warfarin. Monitor for changes in prothrombin time if phytonadione intake (either via supplements or vitamin K-rich foods) is increased or decreased.

Targets

Vitamin K-dependent gamma-carboxylase

Osteocalcin