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QuickView for pilocarpine (compound)

Name: Pilocarpine
PubChem Compound ID: 10285971
Description: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
Molecular formula: C11H17ClN2O2
Molecular weight: 244.718 g/mol
Name: Pilocarpine
Name (isomeric): DB01085
Drug Type: small molecule
Description: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
Spersacarpine; Beta-pilocarpine hydrochloride; Pilocarpine muriate; Pilocarpine HCl; Pilokarpin monohydrochloride; Pilocarpine chloride; Pilocarpine monohydrochloride; Pilocarpine hydrochloride; Adsorbocarpine; Spersacarpine hydrochloride.
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Brand: Pilopine HS, Pilomiotin, Ocusert Pilo-40, Ocusert Pilo-20, Piloptic-2, Almocarpine, Pilocar SMP, Piloptic-1, Epicar, Ocu-Carpine, Akarpine, Isoptocarpine, Pilovisc, Mi-Pilo Ophth Sol, Pilagan, Mistura P, Pilokarpol, Ocusert P 20, Miocarpine, Piloptic-1/2, Amistura P, Pilocel, Pilocarpal, Pilostat, Syncarpine, Ami-Pilo, Ocusert Pilo, Pilocar, Piloptic-3, Piloptic-4, Isopto Carpine, P.V. Carpine Liquifilm, Piloptic-6, Sno Pilo, Salagen, Minims Pilocarpine, Pilocarpol, Mi-Pilo
Brand name mixture:
Timpilo 2(Pilocarpine Hydrochloride + Timolol Maleate), E-Pilo 4 Ophthalmic Solution(Epinephrine Bitartrate + Pilocarpine Hydrochloride), E-Pilo 1 Ophthalmic Solution(Epinephrine bitartrate + Pilocarpine hydrochloride), E-Pilo-4 Oph Soln(Epinephrine Bitartrate + Pilocarpine Hydrochloride), E-Pilo 6 Ophthalmic Solution(Epinephrine Bitartrate + Pi...
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Category: Miotics, Muscarinic Agonists, Cholinergic Agents
CAS number: 54-71-7
Indication: For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome.
Pilocarpine is a choline ester miotic and a positively charged quaternary ammonium compound. Pilocarpine, in appropriate dosage, can increase secretion by the exocrine glands. The sweat, salivary, lacrimal, gastric, pancreatic, and intestinal glands and the mucous cells of the respiratory tract may be stimulated. When applied topically to the eye a...
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Mechanism of Action: Pilocarpine is a cholinergic parasympathomimetic agent. It increase secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors.
Absorption: There was a decrease in the rate of absorption of pilocarpine from SALAGEN Tablets when taken with a high fat meal by 12 healthy male volunteers
Biotransformation: Possibly occurs at the neuronal synapses and in the plasma
Half Life: 0.76 hours
Affected organisms: Humans and other mammals
Drug interaction:
TacrineThe acetylcholinesterase inhibitor, Tacrine, may increase the adverse/toxic effects of Pilocarpine, a cholinergic agonist. Monitor for increased cholinergic effects and toxicity.