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QuickView for piperazine (compound)

Name: piperazine
PubChem Compound ID: 120181
Molecular formula: C4H22N2O6
Molecular weight: 194.227 g/mol
142-63-2; Arpezine; Vermisol; Piperazine hexahydrate; USAF A-3803; AI3-26675; Parid; Piperazine, hexahydrate; 110-85-0; Arthriticine
Name: piperazine
Name (isomeric): DB00592
Drug Type: small molecule
Diethyleneimine; Diketopiperazine; Piperazin [Germany]; Hexahydropyrazine; Diethylenediamine; Prolixin Decanoate; Piperazine hydrate; Piperazin; Piperazine hexahydrate; Glycine anhydride.
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Brand: Antiren, Vermex, Upixon, Moditen, Permitil, Piperazidine, Antepan, Vermidol, Wurmirazin, Tasnon, Lyogen, Entacyl, Siqualone, Eraverm, Pipersol, Dapotum, Omca, Worm-away, Pacinol, Valamina, Dispermine, Asca-Trol No. 3, Lumbrical, Vermizine, Anatensol, Tensofin, Antepar, Bryrel, Worm-A-Ton, Multifuge, Uvilon
Brand name mixture:
Canoids Cap(Aloin + Areca Catechu + Arecoline HBr + Benzocaine + Piperazine Citrate + Santonin), Multi Wormer for Dogs(Dichlorophene + Piperazine (Piperazine Citrate)), Multi Wormer for Cats(Dichlorophene + Piperazine (Piperazine Citrate)), Feloids Tab(Aloin + Areca Catechu + Arecoline HBr + Benzocaine + Piperazine Citrate + Santonin), Ripercol ...
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Category: Anthelmintics, Antinematodal Agents
CAS number: 110-85-0
Indication: Used as alternative treatment for ascariasis caused by <i>Ascaris lumbricoides</i> (roundworm) and enterobiasis (oxyuriasis) caused by <i>Enterobius vermicularis</i> (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.
Pharmacology: Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.
Mechanism of Action: Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.
Absorption: Rapidly absorbed from the gastrointestinal tract
Protein binding: 60-70%
Biotransformation: About 25% is metabolized in the liver. Piperazine is nitrosated to form N -mononitrosopiperazine (MNPz) in gastric juice, which is then metabolized to N-nitroso-3-hydroxypyrrolidine (NHPYR).
Toxicity: LD50 = 5 g/kg (Human, oral). Symptoms of overdose include muscle fatigue, seizures, and difficulty breathing.
Affected organisms: Parasitic nematodes and other roundworms
Food interaction:
Take without regard to meals.