Name: | pregabalin |
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PubChem Compound ID: | 125889 |
Molecular formula: | C8H17NO2 |
Molecular weight: | 159.226 g/mol |
Name: | pregabalin |
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Name (isomeric): | DB00230 |
Drug Type: | small molecule |
Brand: | Lyrica |
Category: | Analgesics, Anticonvulsants |
CAS number: | 148553-50-8 |
Indication: | For management of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. |
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Pharmacology: |
Pregabalin is a new anticonvulsant drug indicated as an add on therapy for partial onset seizures and for certain types of neuropathic pain. It was designed as a more potent successor to a related drug, gabapentin. Pregabalin binds to the alpha2-delta subunit of the voltage-gated calcium channel in the central nervous system. While pregabalin is a ...
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Mechanism of Action: |
Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin is unknown, results with genetically modified mice and with compounds structurally related to pregabalin (such as gabapentin) suggest that binding to ...
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Absorption: | Well absorbed after oral administration. |
Biotransformation: | Negligible |
Route of elimination: | Pregabalin is eliminated from the systemic circulation primarily by renal excretion as unchanged drug. |
Half Life: | ~6 hours |
Clearance: | Renal cl=67.0 – 80.9 mL/min [young healthy subjects] |
Affected organisms: | Humans and other mammals |
Food interaction: |
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Drug interaction: |
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