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QuickView for prilocaine (compound)


PubChem
Name: Prilocaine
PubChem Compound ID: 4906
Description: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
Molecular formula: C13H20N2O
Molecular weight: 220.311 g/mol
Synonyms:
o-Propionotoluidide, 2-(propylamino)-; BRN 2108498; N-(2-Methylphenyl)-2-(propylamino)propanamide; DivK1c_000846; o-Methyl-2-propylaminopropionanilide; (S)-N-(2-Methylphenyl)-2-(propylamino)propanamide; o-Propionotoluidide, 2- (propylamino)-; Prilocainum [INN-Latin]; D00553; Citanest.
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DrugBank
Identification
Name: Prilocaine
Name (isomeric): DB00750
Drug Type: small molecule
Description: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry.
Brand: Citanest Plain, Propitocaine, Astra 1515, Citanest, Astra 1512
Category: Local Anesthetics, Anesthetics, Anesthetics, Local
CAS number: 721-50-6
Pharmacology
Indication: Used as a local anaesthetic and is often used in dentistry.
Pharmacology: Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns.
Mechanism of Action: Prilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.
Protein binding: 98%
Route of elimination: Prilocaine is metabolized in both the liver and the kidney and excreted via the kidney.
Affected organisms: Humans and other mammals

Targets